| Type | Description |
|---|---|
| Definition | abraxas 2, BRISC complex subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 10:38:00 | FAM175B inhibited ATF4 ubiquitination and promoted esophageal squamous cell carcinomas (ESCCs) cell apoptosis in a p53-independent manner. FAM175B expression loss may be an early diagnostic biomarker in ESCC patients. | 30854784 |
| 2019-12-28 10:51:00 | pinpoint a direct interaction between the LNK SH2 domain and a phosphorylated tyrosine residue in KIAA0157 (Abraxas2), a unique and defining BRISC component. | 30755420 |
| 2017-07-15 10:49:00 | In late S/G2 phase, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1, while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1/BRCC36-containing deubiquitinase complex. | 27993934 |
| 2015-12-26 11:49:00 | KIAA0157 allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity. | 26344097 |
| 2015-12-19 10:13:00 | ABRO1 is a novel p53 regulator that plays an important role in tumor suppression and the DNA damage response | 25283148 |
| Type | IDs |
|---|---|
| Synonymous | ABRO1, FAM175B, KIAA0157 |
| Gene |
UniProtKB-ID:
ABRX2_HUMAN
UniprotKB:
Q15018
UniParc:
UPI0000403FD8
EMBL:
AK296677,
BC008999,
D63877
Ensembl:
ENSG00000165660
KO:
hsa:23172
|
| Nucleutide sequences |
EMBL-CDS:
BAG59274.1,
BAA09927.1,
AAH08999.2
Ensembl_TRS:
ENST00000298492
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000298492
RefSeq:
XP_011537856.1,
XP_016871475.1,
NP_115558.3
|
| Others |
UniRef100:
UniRef100_Q15018
UniRef90:
UniRef90_Q15018
UniRef50:
UniRef50_Q15018
UniGene:
Hs.280695
CCDS:
CCDS31308.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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