| Type | Description |
|---|---|
| Definition | F-box and WD-40 domain protein 8 |
| Date | Results | Publications |
|---|---|---|
| 2016-02-27 10:52:00 | FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated | 25790475 |
| 2013-02-23 11:19:00 | mTORC2 negatively feeds back to IRS-1 via control of Fbw8 stability and localization. | 23142081 |
| 2013-01-05 10:53:00 | our data support the concept that expanded ATXN2 undergoes progressive insolubility and affects PABPC1 by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8. | 22956915 |
| 2010-03-22 11:05:00 | Depletion of FBXW8 caused a significant accumulation of cyclin D1, as well as sequestration of CDK1 in the cytoplasm. This resulted in a severe reduction of cell proliferation. | 17205132 |
| 2010-01-21 00:00:00 | FBXW8-CUL7 complex plays a significant role in growth control | 17998335 |
| Type | IDs |
|---|---|
| Synonymous | 4930438M06Rik, FBW6, FBW8, FBXO29, Fbx29 |
| Gene |
UniProtKB-ID:
FBXW8_MOUSE
UniprotKB:
Q8BIA4
UniParc:
UPI00000EB856,
UPI00001D6A1E
EMBL:
AK053794,
AK047756,
BC009095,
BC024091,
AK034447,
AK047695
Ensembl:
ENSMUSG00000032867
KO:
mmu:231672
|
| Nucleutide sequences |
EMBL-CDS:
BAC28712.1,
BAC33147.1,
BAC35527.1,
AAH24091.1,
AAH09095.2,
BAC33128.1
Ensembl_TRS:
ENSMUST00000049474
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000047012
RefSeq:
NP_766309.2
|
| Others |
UniRef100:
UniRef100_Q8BIA4
UniRef90:
UniRef90_Q8BIA4
UniRef50:
UniRef50_Q8BIA4
UniGene:
Mm.221769
CCDS:
CCDS19609.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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