| Type | Description |
|---|---|
| Definition | mitogen-activated protein kinase 8 interacting protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-31 13:13:00 | Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif. | 31690808 |
| 2020-04-04 13:00:00 | MAPK8IP3 variants cause a neurodevelopmental disease which includes spastic diplegia, intellectual disability, cerebral atrophy and corpus callosum hypoplasia. | 30945334 |
| 2020-01-11 10:43:00 | in HT1080 cells, a human fibrosarcoma cell line, a requirement for microtubules, dynein, the JIP3 microtubule motor scaffold protein, and Arf6, a JIP3 interacting protein, for the formation and inward movement of the macropinosome, is reported. | 30969891 |
| 2019-11-23 11:41:00 | implication of de novo variants in MAPK8IP3 as a cause of a neurodevelopmental disorder with intellectual disability and variable brain anomalies | 30612693 |
| 2018-12-01 10:13:00 | JIP3 was highly expressed in hearts with hypertrophic cardiomyopathy. The findings indicated that blockage of JIP3 could alleviate cardiac hypertrophy via inactivating JNK pathway, and thus might be a promising strategy to prevent pathological cardiac hypertrophy. | 29604277 |
| Type | IDs |
|---|---|
| Synonymous | JIP-3, JIP3, JSAP1, SYD2, syd |
| Gene |
UniProtKB-ID:
JIP3_HUMAN,
B7ZMF3_HUMAN,
A0A087WYG2_HUMAN,
E9PFH7_HUMAN
UniprotKB:
Q9UPT6,
B7ZMF3,
A0A087WYG2,
E9PFH7
UniParc:
UPI0000D74C40,
UPI000034ECA7,
UPI000189A8F0,
UPI000387BF89,
UPI000013FFC4
EMBL:
BC137124,
AK024437,
AE006639,
BC150266,
AL031710,
AC012180,
BC144486,
AL031718,
BC137123,
AB028989,
AL031717
Ensembl:
ENSG00000138834
KO:
hsa:23162
|
| Nucleutide sequences |
EMBL-CDS:
AAI37125.1,
AAI50267.1,
BAA83018.2,
CAB72318.1,
AAI37124.1,
BAB15727.1,
AAK61290.1,
AAI44487.1
Ensembl_TRS:
ENST00000250894,
ENST00000610761,
ENST00000356010
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000250894,
ENSP00000481780,
ENSP00000348290
RefSeq:
NP_001305781.1,
XP_024305972.1,
XP_024305977.1,
XP_005255247.1,
XP_011520731.1,
XP_011520732.1,
XP_024305976.1,
NP_001035529.1,
NP_055948.2,
XP_024305978.1,
XP_024305979.1,
XP_024305974.1,
XP_024305971.1,
XP_024305973.1,
XP_024305970.1,
XP_024305975.1,
XP_024305969.1
|
| Others |
UniRef100:
UniRef100_B7ZMF3,
UniRef100_Q9UPT6,
UniRef100_A0A087WYG2,
UniRef100_E9PFH7
UniRef90:
UniRef90_Q9ESN9
UniRef50:
UniRef50_Q9ESN9
UniGene:
Hs.207763
CCDS:
CCDS10442.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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