| Type | Description |
|---|---|
| Definition | ankyrin repeat and LEM domain containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 11:48:00 | that NS4A, ANKLE2, VRK1, and LLGL1 define a pathway impinging on asymmetric determinants of neural stem cell division | 31735666 |
| 2019-01-05 11:28:00 | LEM4 represents a prognostic marker and an attractive target for breast cancer therapeutics. | 30301939 |
| 2018-09-01 11:15:00 | Absence of ANKLE2 severely compromises the post mitotic re-association of the nuclear proteins BAF, LAP2alpha and LaminA to chromosomes. These defects give rise to a strong mechanical instability of the nuclear envelope in telophase and to a chromosomal instability leading to increased number of hyperploid cells. | 29254732 |
| 2017-08-05 11:54:00 | ANKLE2 acetylation at K302 and phosphorylation at S662 are dynamically regulated throughout the cell cycle by SIRT2 and are essential for normal nuclear envelope reassembly. | 27875273 |
| 2012-09-22 10:22:00 | By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans. | 22770216 |
| Type | IDs |
|---|---|
| Synonymous | KIAA0692, LEMD7, Lem4, MCPH16 |
| Gene |
UniProtKB-ID:
ANKL2_HUMAN
UniprotKB:
Q86XL3
UniParc:
UPI00001FBFBB,
UPI00001981FB,
UPI00006C1300
EMBL:
BC082962,
AK093451,
AK293028,
BC001530,
BC062373,
AC136467,
BC043157,
BC025347,
AK024061,
AB014592,
AC135586
Ensembl:
ENSG00000176915
KO:
hsa:23141
|
| Nucleutide sequences |
EMBL-CDS:
BAA31667.1,
AAH25347.1,
BAG52720.1,
BAG51259.1,
AAH62373.1,
BAF85717.1,
AAH82962.1,
AAH01530.2,
AAH43157.2
Ensembl_TRS:
ENST00000542282,
ENST00000542657,
ENST00000357997
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000437807,
ENSP00000350686,
ENSP00000438551
RefSeq:
XP_024304667.1,
XP_011533090.1,
XP_006719798.1,
XP_005266217.1,
XP_011533089.1,
XP_005266216.1,
NP_055929.1
|
| Others |
UniRef100:
UniRef100_Q86XL3
UniRef90:
UniRef90_Q86XL3
UniRef50:
UniRef50_Q86XL3
UniGene:
Hs.654628
CCDS:
CCDS41869.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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