| Type | Description |
|---|---|
| Definition | polymerase PB2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 11:55:00 | Key amino acids in the PB2 and M1 proteins of H7N9 influenza virus that affect its transmission in guinea pigs. | 31597771 |
| 2020-01-18 10:10:00 | The PB2 N567D, T598V, A613V or F636L mutations promoted PB2 627E polymerase activity and chANP32A-X1 showed additive effects, providing further support that species-specific regulation of ANP32A might be only relevant with the PB2 E627K mutation. | 31608791 |
| 2018-12-22 11:34:00 | Data suggest that introduction of the mammalian adaptation mutations into the polymerase basic protein 2 (PB2) gene of duck H7N9 viruses, which are genetically unrelated to the zoonotic H7N9 lineage, can enhance pathogenicity in mice. can enhance pathogenicity in mice. | 28539661 |
| 2017-07-01 11:13:00 | The PB2-V598T/I substitutions substantially increased virus replication and virulence in mice | 27889648 |
| 2016-09-24 12:18:00 | dual 627K and 701N mutations could readily occur during transmission of the virus among ferrets via direct physical contact, and these mutations conferred higher polymerase activity and improved viral replication in mammalian cells | 26391278 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
R4NN18_9INFA
UniprotKB:
R4NN18
UniParc:
UPI00032B3C10
EMBL:
KF021594
KO:
vg:23104219
|
| Nucleutide sequences |
EMBL-CDS:
AGL44433.1
|
| Protein sequencees |
RefSeq:
YP_009118470.1
|
| Others |
UniRef100:
UniRef100_R4NN18
UniRef90:
UniRef90_P03427
UniRef50:
UniRef50_P03427
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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