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23098 SARM1

23098

SARM1

sterile alpha and TIR motif containing 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition sterile alpha and TIR motif containing 1

研究结论

Date Results Publications
2021-03-20 13:33:00 Structural basis for SARM1 inhibition and activation under energetic stress. 33185189
2020-11-21 13:11:00 The SARM1 axon degeneration pathway: control of the NAD(+) metabolome regulates axon survival in health and disease. 32311648
2020-10-10 12:59:00 Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. 31484833
2020-06-20 11:34:00 These results highlight the importance of oligomerization for SARM1 function and reveal critical epitopes for future targeted drug development. 31278906
2019-04-20 11:27:00 SARM1 is phosphorylated at Ser-548 by c-jun-N-terminal kinase under conditions of oxidative stress, and this increases SARM1's NADase activity, leading to inhibited mitochondrial respiration and decreased levels of NAD+ and ATP. 30333228

名称对应

Type IDs
Synonymous MyD88-5, SAMD2, SARM
Gene
UniProtKB-ID: SARM1_HUMAN, Q0D2N8_HUMAN, Q05B42_HUMAN
UniprotKB: Q6SZW1, Q0D2N8, Q05B42
UniParc: UPI0000E531BB, UPI000021FB54, UPI0000E0CAE7, UPI000006E5D8
EMBL: AY444166, AB011096, BC040429, BC122860, AJ290445
Ensembl: ENSG00000004139
KO: hsa:23098
Nucleutide sequences
EMBL-CDS: BAA25450.1, CAB90355.1, AAR17520.1, AAH40429.1, AAI22861.1
Ensembl_TRS: ENST00000585482
Protein sequencees
Ensembl_PRO: ENSP00000468032
RefSeq: NP_055892.2
Others
UniRef100: UniRef100_Q6SZW1, UniRef100_Q05B42
UniRef90: UniRef90_Q6SZW1, UniRef90_A0A452DP93
UniRef50: UniRef50_Q6SZW1, UniRef50_I3L5V6
UniGene: Hs.743510
CCDS: CCDS11230.2

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