| Type | Description |
|---|---|
| Definition | sterile alpha and TIR motif containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:33:00 | Structural basis for SARM1 inhibition and activation under energetic stress. | 33185189 |
| 2020-11-21 13:11:00 | The SARM1 axon degeneration pathway: control of the NAD(+) metabolome regulates axon survival in health and disease. | 32311648 |
| 2020-10-10 12:59:00 | Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. | 31484833 |
| 2020-06-20 11:34:00 | These results highlight the importance of oligomerization for SARM1 function and reveal critical epitopes for future targeted drug development. | 31278906 |
| 2019-04-20 11:27:00 | SARM1 is phosphorylated at Ser-548 by c-jun-N-terminal kinase under conditions of oxidative stress, and this increases SARM1's NADase activity, leading to inhibited mitochondrial respiration and decreased levels of NAD+ and ATP. | 30333228 |
| Type | IDs |
|---|---|
| Synonymous | MyD88-5, SAMD2, SARM |
| Gene |
UniProtKB-ID:
SARM1_HUMAN,
Q0D2N8_HUMAN,
Q05B42_HUMAN
UniprotKB:
Q6SZW1,
Q0D2N8,
Q05B42
UniParc:
UPI0000E531BB,
UPI000021FB54,
UPI0000E0CAE7,
UPI000006E5D8
EMBL:
AY444166,
AB011096,
BC040429,
BC122860,
AJ290445
Ensembl:
ENSG00000004139
KO:
hsa:23098
|
| Nucleutide sequences |
EMBL-CDS:
BAA25450.1,
CAB90355.1,
AAR17520.1,
AAH40429.1,
AAI22861.1
Ensembl_TRS:
ENST00000585482
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000468032
RefSeq:
NP_055892.2
|
| Others |
UniRef100:
UniRef100_Q6SZW1,
UniRef100_Q05B42
UniRef90:
UniRef90_Q6SZW1,
UniRef90_A0A452DP93
UniRef50:
UniRef50_Q6SZW1,
UniRef50_I3L5V6
UniGene:
Hs.743510
CCDS:
CCDS11230.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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