ZNF423 - zinc finger protein 423-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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23090 ZNF423

基因描述

Type	Description
Definition	zinc finger protein 423

研究结论

Date	Results	Publications
2020-11-21 13:18:00	ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities.	32925911
2020-05-02 10:29:00	The present study denoted that ZNF423 is an oxidative stress-responsive gene with an oncogenic property contributing to the regulation of CCA genesis.	31284679
2020-02-22 12:38:00	Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.	31283791
2018-04-28 11:39:00	We identified calmodulin-like protein 3 (CALML3) as a key sensor of this SNP and a coregulator of ERalpha, which contributes to differential gene transcription regulation in an estrogen and SERM-dependent fashion. Furthermore, using CRISPR/Cas9-engineered ZR75-1 breast cancer cells with different ZNF423 SNP genotypes, striking differences in cellular responses to SERMs and inhibitors, alone or in combination	28821270
2017-10-21 12:34:00	We report that CTSO reduces the protein levels of BRCA1 and ZNF423 through cysteine proteinase-mediated degradation. We also have identified a series of transcription factors of BRCA1 that are regulated by CTSO at the protein level.	28968398

名称对应

Type	IDs
Synonymous	Ebfaz, JBTS19, NPHP14, OAZ, Roaz, ZFP423, Zfp104, hOAZ
Gene	UniProtKB-ID: ZN423_HUMAN, B3KNG7_HUMAN, B7Z9C7_HUMAN, F5H7S1_HUMAN UniprotKB: Q2M1K9, B3KNG7, B7Z9C7, F5H7S1 UniParc: UPI00019153F8, UPI000000120C, UPI000015F4AF, UPI0001892633, UPI0000353ABC EMBL: AC007339, AK304829, BC112315, AF221712, AC007607, KF456193, BC112317, AC007861, AK027479, AC027348, AC007603, AB018303 Ensembl: ENSG00000102935 KO: hsa:23090
Nucleutide sequences	EMBL-CDS: AAI12318.1, AAI12316.1, BAA34480.2, AAF28354.1, BAG51329.1, BAH14263.1 Ensembl_TRS: ENST00000562871, ENST00000563137, ENST00000262383, ENST00000562520, ENST00000561648, ENST00000535559, ENST00000567169
Protein sequencees	Ensembl_PRO: ENSP00000457664, ENSP00000455588, ENSP00000262383, ENSP00000457928, ENSP00000455426, ENSP00000442321, ENSP00000455061 RefSeq: XP_005255913.1, XP_006721234.1, NP_001258549.1, NP_001366215.1, NP_055884.2, NP_001317462.1, XP_016878567.1, XP_016878566.1
Others	UniRef100: UniRef100_F5H7S1, UniRef100_B7Z9C7, UniRef100_Q2M1K9 UniRef90: UniRef90_Q2M1K9 UniRef50: UniRef50_Q2M1K9 UniGene: Hs.530930, Hs.744482 CCDS: CCDS61930.1, CCDS32445.1

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mRNA

Protein

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全选

Pubmed编号	文献信息	发表日期	相关基因
32925911	ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities. PLoS Genet Ojas Deshpande , Raquel Z Lara , Oliver R Zhang , Dorothy Concepcion , Bruce A Hamilton	2020-09-01	-
31284679	Roles of Zinc Finger Protein 423 in Proliferation and Invasion of Cholangiocarcinoma through Oxidative Stress. Biomolecules Timpika Chaiprasert , Napat Armartmuntree , Anchalee Techasen , Chadamas Sakonsinsiri , Somchai Pinlaor , Piti Ungarreevittaya , Narong Khuntikeo , Nisana Namwat , Raynoo Thanan	2019-07-07	-
31283791	Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease. PLoS One Emily Baker , Rebecca Sims , Ganna Leonenko , Aura Frizzati , Janet C Harwood , Detelina Grozeva , GERAD/PERADES , CHARGE , ADGC , EADI , IGAP consortia , Kevin Morgan , Peter Passmore , Clive Holmes , John Powell , Carol Brayne , Michael Gill , Simon Mead , Paola BossÃ¹ , Gianfranco Spalletta , Alison M Goate , Carlos Cruchaga , Wolfgang Maier , Reinhard Heun , Frank Jessen , Oliver Peters , Martin Dichgans , Lutz FrÃ¶Lich , Alfredo Ramirez , Lesley Jones , John Hardy , Dobril Ivanov , Matthew Hill , Peter Holmans , Nicholas D Allen , B Paul Morgan , Sudha Seshadri , Gerard D Schellenberg , Philippe Amouyel , Julie Williams , Valentina Escott-Price	2019-01-01	-
28968398	SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERÎ±-positive breast cancer through regulation of BRCA1. PLoS Genet Junmei Cairns , James N Ingle , Lawrence D Wickerham , Richard Weinshilboum , Mohan Liu , Liewei Wang	2017-10-01	-
28821270	Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion. Breast Cancer Res Sisi Qin , James N Ingle , Mohan Liu , Jia Yu , D Lawrence Wickerham , Michiaki Kubo , Richard M Weinshilboum , Liewei Wang	2017-08-18	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
27727273	Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function. PLoS Genet. Chen-Jei Hong , Bruce A Hamilton	2016-10-01	-
27238639	Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. Cell Metab. Mengle Shao , Jeff Ishibashi , Christine M Kusminski , Qiong A Wang , Chelsea Hepler , Lavanya Vishvanath , Karen A MacPherson , Stephen B Spurgin , Kai Sun , William L Holland , Patrick Seale , Rana K Gupta	2016-06-14	-
26186194	The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin WÃ¼hr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi	2015-07-16	-
26788497	ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies. Biomed Res Int Maria Mesuraca , Emanuela Chiarella , Stefania Scicchitano , Bruna Codispoti , Marco Giordano , Giovanna Nappo , Heather M Bond , Giovanni Morrone	2015-01-01	-

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