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230810 Slc30a2

230810

Slc30a2

solute carrier family 30 (zinc transporter), member 2

protein-coding

Mus musculus

基因描述

Type Description
Definition solute carrier family 30 (zinc transporter), member 2

研究结论

Date Results Publications
2019-09-14 10:20:00 This study confirms that ZnT2 is important for normal breast function in women during lactation, and suggests that women who harbor defective variants in ZnT2 may be at-risk for poor lactation performance. 29476070
2019-07-20 11:19:00 ZnT2 is a novel regulator of vacuolar ATPase assembly, driving lysosome biogenesis, acidification, and tissue remodeling during the initiation of mammary gland involution. 29718697
2016-02-20 10:50:00 Our data implicate ZnT2 as a critical mediator of cell death during involution and importantly, that as an initial involution signal, TNFalpha redistributes ZnT2 to lysosomes to activate LCD 25620235
2015-09-26 10:35:00 dephosphorylated S296 was required to target ZnT2 to accumulate Zn in lysosomes 25808614
2015-09-05 10:45:00 Together, these results demonstrate that ZnT2-mediated zinc transport is critical for mammary gland function, suggesting that defects in ZnT2 not only reduce milk zinc concentration but may compromise breast health 25851903

名称对应

Type IDs
Synonymous ZnT-2, Znt2
Gene
UniProtKB-ID: ZNT2_MOUSE, D3Z5N1_MOUSE
UniprotKB: Q2HJ10, D3Z5N1
UniParc: UPI000059E16E, UPI00001C3161
EMBL: AL669982, BC113751
Ensembl: ENSMUSG00000028836
KO: mmu:230810
Nucleutide sequences
EMBL-CDS: AAI13752.1
Ensembl_TRS: ENSMUST00000105874, ENSMUST00000105872, ENSMUST00000081094
Protein sequencees
Ensembl_PRO: ENSMUSP00000101500, ENSMUSP00000101498, ENSMUSP00000079875
RefSeq: NP_001034766.1, NP_001333507.1, XP_006538818.1
Others
UniRef100: UniRef100_Q2HJ10
UniRef90: UniRef90_Q2HJ10
UniRef50: UniRef50_Q9BRI3-2
UniGene: Mm.358876
CCDS: CCDS38915.1

全选

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研究热度

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