| Type | Description |
|---|---|
| Definition | sestrin 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:34:00 | miR-378a-3p Participates in Metformin's Mechanism of Action on C2C12 Cells under Hyperglycemia. | 33430391 |
| 2021-01-02 12:51:00 | Sestrins teach old T cells new tricks. | 32358171 |
| 2020-04-11 10:11:00 | Sestrins are critical mediators of exercise benefits. Genetic ablation of Sestrins prevents mice from acquiring metabolic benefits of exercise and improving their endurance through training. Sestrin upregulation mimics both molecular and physiological effects of exercise, suggesting that it is a major effector of exercise metabolism. AKT and PGC1alpha are critical for the Sestrin effects in extending endurance. | 31929512 |
| 2020-03-28 10:32:00 | By upregulating AMPK and autophagic activities and suppressing mammalian target of rapamycin complex 1 and oxidative stress, sestrins counteract detrimental effects of doxorubicin on cardiomyocytes. | 31026186 |
| 2019-06-29 10:10:00 | the decreased Sestrin2 levels in aging lead to an impaired AMPK/PGC-1alpha signaling cascade and an increased sensitivity to ischemic insults. | 29325933 |
| Type | IDs |
|---|---|
| Synonymous | HI95, SEST2, Ses2 |
| Gene |
UniProtKB-ID:
SESN2_MOUSE
UniprotKB:
P58043
UniParc:
UPI0000023025
EMBL:
BC005672
Ensembl:
ENSMUSG00000028893
KO:
mmu:230784
|
| Nucleutide sequences |
EMBL-CDS:
AAH05672.1
Ensembl_TRS:
ENSMUST00000030724
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030724
RefSeq:
NP_659156.1
|
| Others |
UniRef100:
UniRef100_P58043
UniRef90:
UniRef90_P58004
UniRef50:
UniRef50_P58004
UniGene:
Mm.23608
CCDS:
CCDS18726.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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