| Type | Description |
|---|---|
| Definition | hypocretin (orexin) receptor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-05 12:57:00 | Involvement of descending pain control system regulated by orexin receptor signaling in the induction of central post-stroke pain in mice. | 32084419 |
| 2020-05-16 12:31:00 | Hcrt excitatory input to cingulate cortex deep layer cells is mediated through HCRTR1 but is unlikely to be involved in the putative role of cortical nNOS/NK1R neurons in sleep homeostasis. | 29462275 |
| 2019-10-26 11:22:00 | Under enforced wakefulness (EW), or after cage change (CC), Hcrtr1 knockout mice exhibited a weakened ability to lower infra-theta; frequencies (1-7 Hz), and mount a robust, narrow-bandwidth, high-frequency theta; rhythm (~8.5 Hz). A fast-gamma (55-80 Hz) response, whose dynamics closely parallelled theta;, also diminished, while beta/slow-gamma activity (15-45 Hz) increased. | 30341359 |
| 2018-12-22 11:21:00 | OX1R expression is associated with a strong specific immunomodulatory effect of orexin-A via OX1R and down-regulation of the pro-inflammatory cytokine production and secretion, as shown in two murine models recapitulating either the acute or chronic phase of ulcerative colitis. | 30251681 |
| 2018-02-24 11:51:00 | Investigated the role of orexin receptors in compulsive-like alcohol drinking, found that systemic administration of the selective OX1R blocker SB-334867 reduced compulsive-like consumption. Results suggest that OX1R signaling is particularly important for promoting compulsive-like alcohol drinking, and that OX1Rs might represent a novel therapy to counteract compulsive aspects of human alcohol use disorders. | 27523303 |
| Type | IDs |
|---|---|
| Synonymous | Ox1r, ox-1-R, ox1-R |
| Gene |
UniProtKB-ID:
OX1R_MOUSE,
Q0VDP6_MOUSE
UniprotKB:
P58307,
Q0VDP6
UniParc:
UPI00001C3120,
UPI000024DE60
EMBL:
AL606925,
AF394596,
CU207372,
BC119582,
AY255599,
AY336083,
BC119583,
CU210846,
AK140137
Ensembl:
ENSMUSG00000028778
KO:
mmu:230777
|
| Nucleutide sequences |
EMBL-CDS:
AAR01326.1,
BAE24252.1,
AAI19584.1,
AAO85111.1,
AAK71326.1,
AAI19583.1
Ensembl_TRS:
ENSMUST00000119423,
ENSMUST00000164887,
ENSMUST00000030562,
ENSMUST00000120154
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000112630,
ENSMUSP00000113198,
ENSMUSP00000030562,
ENSMUSP00000127290
RefSeq:
NP_945197.2,
NP_001156499.1,
NP_001344187.1,
XP_036019955.1,
XP_036019953.1,
XP_017175645.1,
XP_017175646.1,
NP_001292321.1,
XP_036019954.1
|
| Others |
UniRef100:
UniRef100_P58307
UniRef90:
UniRef90_O43613
UniRef50:
UniRef50_O43613
UniGene:
Mm.246595
CCDS:
CCDS18707.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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