| Type | Description |
|---|---|
| Definition | elongator complex protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:13:00 | Loss of Ikbkap/Elp1 in mouse oocytes causes spindle disorganization, developmental defects in preimplantation embryos and impaired female fertility. | 31827135 |
| 2019-03-16 12:36:00 | This splice-switching class of molecules is the first to specifically correct the ELP1 exon 20 splicing defect. Our data provide proof of principle of ExSpeU1s-adeno-associated virus particles as a novel therapeutic strategy for FD. | 29701768 |
| 2018-12-22 10:07:00 | Although mitochondrial impairment was detected in all Ikbkap-deficient retinal neurons, retinal ganglion cells were the only cell type to degenerate; the survival of other retinal neurons was unaffected. | 29929962 |
| 2018-06-23 11:54:00 | data reveal an essential function for Ikbkap that extends beyond the peripheral nervous system to CNS development and function | 28167615 |
| 2017-10-28 11:15:00 | Results show that although Ikbkap is not required for normal development of retinal ganglion cells, its loss causes a slow, progressive retinal ganglion cells degeneration most severely in the temporal retina, which is later followed by indirect photoreceptor loss and complete retinal disorganization. | 27699209 |
| Type | IDs |
|---|---|
| Synonymous | 3110040G09Rik, 6030413P05, C78473, IKAP, Ikbkap |
| Gene |
UniProtKB-ID:
ELP1_MOUSE
UniprotKB:
Q7TT37
UniParc:
UPI0000022EAB
EMBL:
AK035944,
AK004402,
AL807762,
BC052387,
AK076152,
AF140786,
AF367244,
AK147153,
BC054468,
AL929577,
AF387811
Ensembl:
ENSMUSG00000028431
KO:
mmu:230233
|
| Nucleutide sequences |
EMBL-CDS:
BAC29252.1,
BAC36221.1,
AAO15309.1,
AAL40925.1,
AAL36025.1,
BAB23291.1,
AAH54468.1,
BAE27720.1,
AAH52387.2
Ensembl_TRS:
ENSMUST00000030140
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000030140
RefSeq:
NP_080355.2,
XP_030109279.1
|
| Others |
UniRef100:
UniRef100_Q7TT37
UniRef90:
UniRef90_Q7TT37
UniRef50:
UniRef50_Q7TT37
UniGene:
Mm.282743
CCDS:
CCDS38765.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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