| Type | Description |
|---|---|
| Definition | src homology 2 domain-containing transforming protein B |
| Date | Results | Publications |
|---|---|---|
| 2018-06-09 10:39:00 | The absence of the src homology 2 domain-containing transforming protein B (Shb) gene exacerbates the disease in myeloid leukemia, whereas it alters the disease characteristics without affecting latency in B- and T-cell leukemia. | 29792386 |
| 2016-02-20 11:35:00 | The observed aberrations in myeloid cell properties in Shb-deficient mice are likely consequences of an abnormal vascular compartment and are not responsible for reduced muscle blood flow | 25561022 |
| 2016-01-16 11:22:00 | a unique combinatorial response of increased vascular permeability and reduced recruitment of cytotoxic CD8+ cells occurs as a consequence of Shb deficiency in B16F10 melanomas. | 25885274 |
| 2015-01-31 13:16:00 | Data indicate that Src homology-2 domain containing protein B (SHB) deficiency causes a chronic increase in beta-cell focal adhesion kinase (FAK) activity that perturbs the normal insulin secretory characteristics of beta-cells. | 25274988 |
| 2014-09-27 10:59:00 | Data suggest that absence of Src homology-2 protein Shb accelerates disease progression by exerting dual roles in BCR-ABL-induced leukemia: increased cell expansion due to elevated focal adhesion kinase (FAK) activity and neutrophilia in peripheral blood. | 24952416 |
| Type | IDs |
|---|---|
| Synonymous | BC028832 |
| Gene |
UniProtKB-ID:
SHB_MOUSE
UniprotKB:
Q6PD21
UniParc:
UPI00001C2F57,
UPI00005AC421
EMBL:
BC058986,
AK145414,
AL772376
Ensembl:
ENSMUSG00000044813
KO:
mmu:230126
|
| Nucleutide sequences |
EMBL-CDS:
AAH58986.1,
BAE26425.1
Ensembl_TRS:
ENSMUST00000061986
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000060433
RefSeq:
NP_001028478.1
|
| Others |
UniRef100:
UniRef100_Q6PD21
UniRef90:
UniRef90_Q15464
UniRef50:
UniRef50_Q15464
UniGene:
Mm.251716
CCDS:
CCDS51173.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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