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230099 Car9

230099

Car9

carbonic anhydrase 9

protein-coding

Mus musculus

基因描述

Type Description
Definition carbonic anhydrase 9

研究结论

Date Results Publications
2020-05-23 10:46:00 hCA IX and mCA IX are highly similar, and the transcription of both genes is predominantly governed by hypoxia, some attributes of transcriptional regulation are specific for either human or mouse and as such, could result in different tissue expression and data interpretation. 31905844
2019-09-28 11:56:00 In response to hypoxia, pancreatic ductal adenocarcinoma cells that express activated KRAS increase expression of carbonic anhydrase 9, via stabilization of HIF1A and HIF2A, to regulate pH and glycolysis. 31078621
2019-07-20 11:50:00 Lack of CAIX results in persistent acid backflux via claudin-18 downregulation, causing loss of parietal cells, hypergastrinaemia and foveolar hyperplasia. 28748627
2017-12-02 10:52:00 Authors demonstrate that CAIX associates with MMP14 through potential phosphorylation residues within its intracellular domain, and that CAIX enhances MMP14-mediated collagen degradation by directly contributing hydrogen ions required for MMP14 catalytic activity. 28692057
2016-04-09 10:52:00 Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors. 26152355

名称对应

Type IDs
Synonymous CAIX, Ca9, MN/CA9
Gene
UniProtKB-ID: CAH9_MOUSE, Q3UUZ9_MOUSE
UniprotKB: Q8VHB5, Q3UUZ9
UniParc: UPI0000022EC7, UPI00000E8A67
EMBL: BC120546, AY049077, BC120544, AJ245857, AB086322, AK137719, AK136579
Ensembl: ENSMUSG00000028463
KO: mmu:230099
Nucleutide sequences
EMBL-CDS: BAC00816.1, AAL14193.1, CAC80975.1, BAE23474.1, AAI20545.1, AAI20547.1, BAE23060.1
Ensembl_TRS: ENSMUST00000030183
Protein sequencees
Ensembl_PRO: ENSMUSP00000030183
RefSeq: XP_006537894.1, NP_647466.2
Others
UniRef100: UniRef100_Q8VHB5
UniRef90: UniRef90_Q8VHB5
UniRef50: UniRef50_Q16790
UniGene: Mm.283682
CCDS: CCDS18099.1

全选

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