| Type | Description |
|---|---|
| Definition | WD repeat and FYVE domain containing 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-11 10:52:00 | Alfy is required in the adult brain for the autophagy-dependent clearance of proteinaceous deposits, and its depletion in neurons derived from Huntington's disease patient fibroblasts accelerates the aberrant accumulation of this pathological hallmark shared across adult-onset neurodegenerative diseases. | 31899071 |
| 2020-05-16 12:38:00 | Proliferating cortical neural progenitors of human embryonic brain regions highly express WDFY3. | 31327001 |
| 2019-07-06 12:50:00 | a crucial role for ALFY in retinoid triggered maturation of acute myeloid leukemia cells, is reported. | 29021535 |
| 2019-05-30 11:36:00 | The Autophagy linked FYVE protein (Alfy), also known as WDFY3, is required for development of the central nervous system (CNS) in mice. | 27648578 |
| 2016-08-06 11:17:00 | we demonstrate that normally ALFY attenuates the canonical Wnt signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 or Dvl2. | 27008544 |
| Type | IDs |
|---|---|
| Synonymous | ALFY, BCHS, MCPH18, ZFYVE25 |
| Gene |
UniProtKB-ID:
WDFY3_HUMAN,
A0A024RDC2_HUMAN
UniprotKB:
Q8IZQ1,
A0A024RDC2
UniParc:
UPI0000D8985C,
UPI000013E2C7
EMBL:
BC065502,
BC119633,
BC015214,
CH471057,
AK055806,
AC095046,
AK094910,
AC104082,
AB023210,
BC013377,
AF538685
Ensembl:
ENSG00000163625
KO:
hsa:23001
|
| Nucleutide sequences |
EMBL-CDS:
BAA76837.2,
AAH13377.1,
BAB71020.1,
AAH15214.2,
AAY40903.1,
AAI19634.1,
AAH65502.1,
BAC04455.1,
AAN15137.1,
EAX05955.1,
EAX05953.1,
EAX05952.1
Gene_ORFName:
hCG_15053
Ensembl_TRS:
ENST00000295888
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000295888
RefSeq:
XP_011530065.1,
XP_011530068.1,
XP_005262915.1,
XP_011530059.1,
XP_011530066.1,
XP_016863396.1,
XP_016863398.1,
NP_055806.2,
XP_011530067.1,
XP_011530063.1,
XP_011530062.1,
XP_011530061.1,
XP_011530069.1,
XP_016863397.1,
XP_011530064.1,
XP_016863395.1
|
| Others |
UniRef100:
UniRef100_Q8IZQ1
UniRef90:
UniRef90_Q8IZQ1
UniRef50:
UniRef50_Q8IZQ1
UniGene:
Hs.480116,
Hs.726339
CCDS:
CCDS3609.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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