| Type | Description |
|---|---|
| Definition | SREBF chaperone |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:35:00 | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. | 33446483 |
| 2020-12-12 13:25:00 | Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP. | 32054686 |
| 2020-08-22 15:24:00 | Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children. | 31003232 |
| 2019-11-09 10:23:00 | cholesterol inhibited the progression of HCC through restraining SCAP-mediated fatty acid de novo synthesis. | 30638930 |
| 2019-07-20 11:52:00 | GP73 is indispensable for SREBPs activation and lipogenesis. Notably, GP73 overexpression enhanced SCAP-SREBP1 binding and its Golgi trafficking even under cholesterol sufficiency. | 29097707 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SCAP_HUMAN,
B7Z6H0_HUMAN
UniprotKB:
Q12770,
B7Z6H0
UniParc:
UPI0000140776,
UPI000019B50C,
UPI000019B50D,
UPI0000135624,
UPI0001914F2B
EMBL:
AK027402,
BC020987,
AK075528,
D83782,
AK300311
Ensembl:
ENSG00000114650
KO:
hsa:22937
|
| Nucleutide sequences |
EMBL-CDS:
BAA12111.2,
AAH20987.1,
BAB55088.1,
BAC11673.1,
BAH13256.1
Gene_ORFName:
PSEC0227
Ensembl_TRS:
ENST00000265565,
ENST00000648151
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000497087,
ENSP00000265565
RefSeq:
NP_001306973.1,
NP_036367.2,
XP_011531803.1,
XP_016861407.1,
XP_016861410.1,
XP_005265028.1,
XP_005265025.1,
XP_011531804.1,
XP_005265024.1
|
| Others |
UniRef100:
UniRef100_B7Z6H0,
UniRef100_Q12770
UniRef90:
UniRef90_P97260,
UniRef90_B7Z6H0
UniRef50:
UniRef50_P97260
UniGene:
Hs.531789
CCDS:
CCDS2755.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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