| Type | Description |
|---|---|
| Definition | elongation factor for RNA polymerase II 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 11:02:00 | MRCCAT1 is upregulated in glioma, predicting poor outcome for patients. MRCCAT1 promotes glioma cell proliferation and migration by activating p38-MAPK signaling. | 30556882 |
| 2019-06-08 12:11:00 | ELL2 protein was downregulated in prostate cancer specimens and was up-regulated by androgens in prostate cancer cell lines LNCaP and C4-2. ELL2 knockdown enhanced prostate cancer cell proliferation and motility. | 30009504 |
| 2018-12-22 12:06:00 | Study in CD138+ plasma cells from 1630 multiple myeloma (MM) patients show that the MM risk allele at 5q15 lowers ELL2 expression in these cells, but not in peripheral blood or other tissues. | 29695719 |
| 2018-11-24 10:24:00 | Study reports the 2.0-A resolution crystal structure of the human ELL2 C-terminal domain bound to its 50-residue binding site on AFF4, the ELLBow. The ELLBow consists of an N-terminal helix followed by an extended hairpin and occupies most of the concave surface of ELL2. This surface is important for the ability of ELL2 to promote HIV-1 Tat-mediated proviral transcription. | 28134250 |
| 2018-10-27 10:49:00 | Knockdown of RNA polymerase II elongation factor ELL2 (ELL2) sensitized prostate cancer cells to DNA damage and overexpression of ELL2 protected prostate cancer cells from DNA damage. | 29179998 |
| Type | IDs |
|---|---|
| Synonymous | MRCCAT1 |
| Gene |
UniProtKB-ID:
ELL2_HUMAN,
Q59FW6_HUMAN,
Q7Z656_HUMAN
UniprotKB:
O00472,
Q59FW6,
Q7Z656
UniParc:
UPI00017A78BC,
UPI00001A9DE6,
UPI000013CA27,
UPI00004F6C73
EMBL:
BC028412,
U88629,
AC008592,
AK297956,
BX538289,
AB209343
Ensembl:
ENSG00000118985
KO:
hsa:22936
|
| Nucleutide sequences |
EMBL-CDS:
BAG60269.1,
AAH28412.1,
AAC51232.1,
BAD92580.1,
CAD98084.1
Ensembl_TRS:
ENST00000237853
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000237853
RefSeq:
XP_016864729.1,
XP_016864728.1,
XP_016864732.1,
XP_016864730.1,
NP_036213.2,
XP_016864731.1,
XP_006714638.1
|
| Others |
UniRef100:
UniRef100_O00472,
UniRef100_Q7Z656
UniRef90:
UniRef90_Q7Z656,
UniRef90_O00472
UniRef50:
UniRef50_Q7Z656,
UniRef50_O00472
UniGene:
Hs.192221,
Hs.708710
CCDS:
CCDS4080.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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