| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 2A |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 10:36:00 | eIF2alphaP is a nodal point of mTORC1 signaling, which can determine the susceptibility of TSC2-deficient cells to oxidative insults and their efficacy in tumor formation in mice maintained on antioxidant diet. | 29449538 |
| 2020-02-15 10:39:00 | phosphorylation of eIF2alpha was mediated via protein kinase R (PKR), but further investigation revealed that PKR activation, phosphorylation of eIF2alpha, and translational arrest were uncoupled during viral infection | 31213553 |
| 2019-03-23 11:40:00 | CReP deletion activates a linear signaling pathway involving eIF2alpha phosphorylation, ATF4 translation, and FGF21 induction, which promotes increased energy expenditure, and subsequently improved obesity-related metabolic parameters. | 29698569 |
| 2019-01-12 12:21:00 | The data show that activating transcription factor 4 is not required, but eukaryotic initiation factor 2 alpha phosphorylation is necessary to prevent mTORC1 activation during amino acid stress. | 29449374 |
| 2018-07-28 11:11:00 | HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation. | 29233968 |
| Type | IDs |
|---|---|
| Synonymous | D030048D22, D3Ertd194e |
| Gene |
UniProtKB-ID:
EIF2A_MOUSE
UniprotKB:
Q8BJW6
UniParc:
UPI00001C2B83,
UPI0000E5743D
EMBL:
BC082557,
AK078519,
BC030447
Ensembl:
ENSMUSG00000027810
KO:
mmu:229317
|
| Nucleutide sequences |
EMBL-CDS:
AAH82557.1,
BAC37320.1,
AAH30447.1
Ensembl_TRS:
ENSMUST00000029387
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000029387
RefSeq:
NP_001005509.1,
XP_006501384.1,
XP_036018930.1
|
| Others |
UniRef100:
UniRef100_Q8BJW6
UniRef90:
UniRef90_Q9BY44
UniRef50:
UniRef50_Q9BY44
UniGene:
Mm.21617
CCDS:
CCDS17367.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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