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22924 MAPRE3

22924

MAPRE3

microtubule associated protein RP/EB family member 3

protein-coding

Homo sapiens

基因描述

Type Description
Definition microtubule associated protein RP/EB family member 3

研究结论

Date Results Publications
2020-08-01 14:20:00 structure prediction of the C-terminal domain of the microtubule end-binding protein 3 32421702
2020-04-04 10:18:00 Extracellular recordings revealed that the V337M tau mutation leads to an abnormal increase in neuronal activity in response to chronic depolarization. In neurons with this mutation, axon initial segment (AIS) plasticity is impaired by the abnormal accumulation of end-binding protein 3 (EB3) in the AIS submembrane region. 31542321
2019-06-08 10:52:00 IP3K-A binds to EB3 and their binding affinity is precisely regulated by protein kinase A phosphorylation of IP3K-A at Ser119 (pSer119). The complex of IP3K-A and EB3 dissociates and reassociates rapidly during chemically induced LTP. 30466786
2017-12-02 11:10:00 One candidate pathway coupling actin filaments to microtubules consists of the actin filament-binding protein drebrin and the microtubule-binding +TIP protein EB3. This pathway is regulated proximally by cyclin-dependent kinase 5 phosphorylation of drebrin but the upstream elements in the pathway have yet to be identified. 28865014
2017-10-07 12:27:00 EB1 and EB3 thus affect multiple interphase processes and have a major impact on microtubule minus end organization. 28814570

名称对应

Type IDs
Synonymous EB3, EBF3, EBF3-S, RP3
Gene
UniProtKB-ID: MARE3_HUMAN
UniprotKB: Q9UPY8
UniParc: UPI000012EB1C, UPI00004CE218
EMBL: CR541845, CH471053, AC013472, AF288787, Y11174, CR536523, AB025186, BC011557
Ensembl: ENSG00000084764
KO: hsa:22924
Nucleutide sequences
EMBL-CDS: EAX00662.1, CAA72060.1, AAY14653.1, BAA82958.1, CAG38760.1, AAK07556.1, EAX00663.1, AAH11557.1, EAX00666.1, CAG46643.1, EAX00660.1, AAK07557.1
Ensembl_TRS: ENST00000402218, ENST00000405074, ENST00000233121, ENST00000648289
Protein sequencees
Ensembl_PRO: ENSP00000385715, ENSP00000497057, ENSP00000233121, ENSP00000383915
RefSeq: NP_036458.2, XP_016859086.1, XP_006712030.1, XP_011531002.1, NP_001289979.1
Others
UniRef100: UniRef100_Q9UPY8
UniRef90: UniRef90_Q9UPY8
UniRef50: UniRef50_Q9UPY8
UniGene: Hs.515860
CCDS: CCDS1731.1

全选

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