| Type | Description |
|---|---|
| Definition | FANCD2 and FANCI associated nuclease 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:10:00 | Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects. | 32589923 |
| 2019-06-22 10:59:00 | We show that FAN1 binds to the expanded HTT CAG repeat DNA and its nuclease activity is not required for protection against CAG repeat expansion. These data shed new mechanistic insights into how the genetic modifiers of Huntington's disease (HD) act to alter disease progression and show that FAN1 affects somatic expansion of the CAG repeat through a nuclease-independent mechanism. | 30358836 |
| 2019-05-18 12:22:00 | The results of our study argue against the implication of pathogenic variants of FAN1 in unexplained cases of suspected genetic predisposition to colorectal polyps/cancer. | 30639725 |
| 2018-08-18 11:11:00 | hFAN1 homodimerization plays a role in biological processes that involve 5' DNA Flap cleavage. | 29518739 |
| 2018-04-21 10:46:00 | FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2 | 29051491 |
| Type | IDs |
|---|---|
| Synonymous | KIAA1018, KMIN, MTMR15, hFAN1 |
| Gene |
UniProtKB-ID:
FAN1_HUMAN
UniprotKB:
Q9Y2M0
UniParc:
UPI000006D713,
UPI000000DABD
EMBL:
AC087481,
BC047882,
AB023235,
AK290987
Ensembl:
ENSG00000198690,
ENSG00000276787
KO:
hsa:22909
|
| Nucleutide sequences |
EMBL-CDS:
BAA76862.3,
BAF83676.1,
AAH47882.1
Ensembl_TRS:
ENST00000670849,
ENST00000561594,
ENST00000565466,
ENST00000658773,
ENST00000657391,
ENST00000656435,
ENST00000621063,
ENST00000362065,
ENST00000561607
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000499703,
ENSP00000354497,
ENSP00000454544,
ENSP00000455983,
ENSP00000499534,
ENSP00000484956,
ENSP00000499638,
ENSP00000499742,
ENSP00000454223
RefSeq:
XP_016877502.1,
NP_001139568.1,
XP_024305642.1,
XP_016877501.1,
NP_001139566.1,
XP_005254289.1,
XP_005254291.1,
XP_011519674.1,
NP_055782.3,
XP_011519673.1,
XP_005254292.1,
NP_001139567.1,
XP_011519672.1
|
| Others |
UniRef100:
UniRef100_Q9Y2M0
UniRef90:
UniRef90_Q9Y2M0
UniRef50:
UniRef50_Q9Y2M0
UniGene:
Hs.584863
CCDS:
CCDS58344.1,
CCDS32186.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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