| Type | Description |
|---|---|
| Definition | proteasome (prosome, macropain) inhibitor subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 12:38:00 | Inactivation of PI31 in mouse neurons attenuated proteasome movement in axons, indicating this process is conserved. Because mutations affecting PI31 activity are associated with human neurodegenerative diseases, impairment of PI31-mediated axonal transport of proteasomes may contribute to these disorders. | 31327739 |
| 2020-04-18 10:09:00 | Study in global and conditional PI31 knockout mouse establishes a critical role for PI31 and protein degradation in the maintenance of neuronal architecture, circuitry, and function. Because mutations that impair PI31 function are thought to cause neurodegenerative diseases in humans, reduced PI31 activity may contribute to age-related neurodegenerative diseases. | 31754024 |
| 2010-01-21 00:00:00 | PI31 acts as a selective modulator of the proteasome-mediated steps in MHC class I antigen processing | 12374861 |
| Type | IDs |
|---|---|
| Synonymous | AW048666, BC012260, PI31 |
| Gene |
UniProtKB-ID:
PSMF1_MOUSE,
A0A1S6GWI1_MOUSE,
A2AU35_MOUSE
UniprotKB:
Q8BHL8,
A0A1S6GWI1,
A2AU35
UniParc:
UPI00000EB909,
UPI0003D7589C
EMBL:
AK031363,
BC131928,
AK045891,
AK053924,
AK078867,
BC131930,
KY499691
Ensembl:
ENSMUSG00000032869
KO:
mmu:228769
|
| Nucleutide sequences |
EMBL-CDS:
BAC37430.1,
BAC35596.1,
BAC27368.1,
BAC32522.1,
AQS27612.1,
AAI31931.1,
AAI31929.1
Ensembl_TRS:
ENSMUST00000109869,
ENSMUST00000042452
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041184,
ENSMUSP00000105495
RefSeq:
NP_001292173.1,
NP_997611.1,
XP_006499369.1
|
| Others |
UniRef100:
UniRef100_Q8BHL8
UniRef90:
UniRef90_Q8BHL8
UniRef50:
UniRef50_Q8BHL8
UniGene:
Mm.146984
CCDS:
CCDS16872.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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