| Type | Description |
|---|---|
| Definition | activating transcription factor 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-05 12:58:00 | Dominant-Negative ATF5 Compromises Survival by Targeting CEBPB and CEBPD. | 31676720 |
| 2020-08-29 12:49:00 | Expression of activating transcription factor 5 (ATF5) is mediated by microRNA-520b-3p under diverse cellular stress in cancer cells. | 32603335 |
| 2018-12-22 11:40:00 | Data suggest that ATF5 is modified by SUMO2/3 at a conserved SUMO-targeting consensus site; this SUMOylation of ATF5 appears to be required for transport of ATF5 to centrosome. (ATF5 = activating transcription factor-5; SUMO = small ubiquitin-like modifier) | 29326161 |
| 2018-06-16 11:23:00 | Study reports that reduced levels of ATF5 in brain of Huntington's disease patients, probably due to its sequestration into the characteristic PolyQ containing neuronal inclusion bodies, correlates with decreased levels of the antiapoptotic protein MCL1, a transcriptional target of ATF5. Also provides evidence of decreased ATF5 being deleterious by rendering neurons more vulnerable to polyQ-induced apoptosis. | 28861715 |
| 2017-12-30 10:43:00 | ATF5 expression can rescue UPR(mt) signaling in atfs-1-deficient worms requiring the same UPR(mt) promoter element identified in C. elegans. Furthermore, mammalian cells require ATF5 to maintain mitochondrial activity during mitochondrial stress and promote organelle recovery. Combined, these data suggest that regulation of the UPR(mt) is conserved from worms to mammals. | 27426517 |
| Type | IDs |
|---|---|
| Synonymous | ATFX, HMFN0395 |
| Gene |
UniProtKB-ID:
ATF5_HUMAN,
A0A024QZG3_HUMAN
UniprotKB:
Q9Y2D1,
A0A024QZG3
UniParc:
UPI000003842F
EMBL:
AB073613,
AF101388,
AF305687,
AC011452,
AK024402,
AB021663,
BC005174,
CH471177
Ensembl:
ENSG00000169136
KO:
hsa:22809
|
| Nucleutide sequences |
EMBL-CDS:
BAG51295.1,
BAA78477.2,
AAH05174.1,
BAD38650.1,
AAG22558.1,
EAW52581.1,
AAD28370.1,
EAW52582.1
Gene_ORFName:
hCG_21104
Ensembl_TRS:
ENST00000595125,
ENST00000423777
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000470633,
ENSP00000396954
RefSeq:
NP_036200.2,
NP_001277675.1,
XP_011524931.1,
NP_001180575.1
|
| Others |
UniRef100:
UniRef100_Q9Y2D1
UniRef90:
UniRef90_Q9Y2D1
UniRef50:
UniRef50_Q9Y2D1
UniGene:
Hs.9754
CCDS:
CCDS12789.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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