| Type | Description |
|---|---|
| Definition | aph1 homolog A, gamma secretase subunit |
| Date | Results | Publications |
|---|---|---|
| 2019-04-13 11:44:00 | This work provides novel evidence for the role of miRNAs in memory formation and demonstrates the implication of APH1a protein in miRNA processing in the adult brain. | 30663934 |
| 2017-06-10 10:29:00 | Prostaglandin I2 accumulation in neuronal cells activates and JNK/c-Jun signaling pathways by phosphorylation, which results in APH-1alpha/1beta expression. | 27240539 |
| 2017-05-20 14:34:00 | Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase. | 27349870 |
| 2016-05-28 11:13:00 | Abeta oligomers in the cerebrospinal fluid (CSF) further promoted the expression of APH-1alpha/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP and Abeta deposition during AD progression | 26293690 |
| 2014-02-07 17:09:00 | Upregulation of PS1/gamma-secretase activity may be a risk factor for late onset sporadic Alzheimer's disease. | 22140537 |
| Type | IDs |
|---|---|
| Synonymous | 6530402N02Rik, APH-1a |
| Gene |
UniProtKB-ID:
APH1A_MOUSE,
Q6GTF1_MOUSE
UniprotKB:
Q8BVF7,
Q6GTF1
UniParc:
UPI00000E594A,
UPI0000021416
EMBL:
BC012406,
BC024111,
BC057865,
AK148400,
AK078343
Ensembl:
ENSMUSG00000015750
KO:
mmu:226548
|
| Nucleutide sequences |
EMBL-CDS:
AAH24111.1,
AAH12406.1,
BAC37228.1,
AAH57865.1,
BAE28531.1
Ensembl_TRS:
ENSMUST00000015894,
ENSMUST00000056710
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000058846,
ENSMUSP00000015894
RefSeq:
NP_666216.1,
NP_666246.1
|
| Others |
UniRef100:
UniRef100_Q6GTF1,
UniRef100_Q8BVF7
UniRef90:
UniRef90_Q6GTF1,
UniRef90_Q8BVF7
UniRef50:
UniRef50_Q96BI3,
UniRef50_G3W524
UniGene:
Mm.306954,
Mm.337825,
Mm.486756
CCDS:
CCDS50999.1,
CCDS17624.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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