| Type | Description |
|---|---|
| Definition | twinkle mtDNA helicase |
| Date | Results | Publications |
|---|---|---|
| 2017-07-01 13:01:00 | Twinkle overexpression alleviated impaired mitochondrial biogenesis in the border area through maintained mtDNA copy number and thereby prevented cardiac rupture accompanied by the reduction of apoptosis and oxidative stress, and suppression of MMP activity. | 27342873 |
| 2016-02-27 11:28:00 | Twinkle overexpression results in increased mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress. | 25822152 |
| 2014-03-22 11:42:00 | study describes findings in a family with late onset parkinsonism and progressive external ophthalmoplegia, with mutation of G1750A in the exon 1 of PEO1 gene | 24076137 |
| 2013-11-02 11:33:00 | TWINKLE is essential for nascent H-strand synthesis in the D-loop, thus showing that there is no separate DNA helicase responsible for replication of this region. | 23393161 |
| 2013-04-13 11:02:00 | mammalian Twinkle is important for mitochondrial integrity in DA neurons and provide a novel mouse model in which increased mtDNA deletions may lead to DA neuron degeneration and parkinsonism. | 22949510 |
| Type | IDs |
|---|---|
| Synonymous | D19Ertd626e, PEO, Peo1, Twinl |
| Gene |
UniProtKB-ID:
PEO1_MOUSE,
Q3V303_MOUSE,
A0A494B8Y2_MOUSE
UniprotKB:
Q8CIW5,
Q3V303,
A0A494B8Y2
UniParc:
UPI00000E7580,
UPI0000027A80,
UPI00005AB730,
UPI0003D76B37
EMBL:
AK054159,
AC132957,
BC071195,
AK146244,
BC034909,
AY059385
Ensembl:
ENSMUSG00000025209
KO:
mmu:226153
|
| Nucleutide sequences |
EMBL-CDS:
BAE27008.1,
AAL27647.1,
AAH71195.1,
AAH34909.1,
BAE20696.1
Ensembl_TRS:
ENSMUST00000026227,
ENSMUST00000236685
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026227,
ENSMUSP00000157397
RefSeq:
NP_001335183.1,
NP_722491.2,
NP_001335188.1
|
| Others |
UniRef100:
UniRef100_Q3V303,
UniRef100_Q8CIW5
UniRef90:
UniRef90_Q8CIW5,
UniRef90_Q8CIW5-2
UniRef50:
UniRef50_Q8CIW5-2,
UniRef50_Q96RR1
UniGene:
Mm.105585
CCDS:
CCDS29854.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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