| Type | Description |
|---|---|
| Definition | X-ray repair complementing defective repair in Chinese hamster cells 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 10:58:00 | demonstrated that Xrcc1 deficiency in primordial germ cells induced elevated levels of reactive oxygen species, mitochondria dysfunction, apoptosis, and loss of stemness of spermatogonial stem cells (SSCs) in testes. In Xrcc1-deficienct SSCs, elevated oxidative stress and mitochondrial dysfunction could be partially reversed by treatment with the antioxidant N-acetylcysteine | 30998386 |
| 2020-05-16 13:00:00 | SIRT1 confers chemoresistance to lung cancer cells by deacetylating and stabilizing XRCC1. | 31043584 |
| 2018-12-22 11:28:00 | Unrepaired single strand DNA breaks (SSBs) activate DNA damage response and increase the expression of inflammatory cytokines through NF-kappaB signalling. Pressure overload-induced heart failure is more severe in the mice lacking XRCC1, an essential protein for SSB repair. | 28436431 |
| 2018-08-18 10:19:00 | Interaction with phosphorylated XRCC1 is a requirement for significant APTX recruitment to cellular DNA damage and enzymatic activity in cell extracts. | 29477978 |
| 2018-02-10 11:44:00 | this review focuses on the role of the oxidized form of XRCC1 in protection against extreme oxidative stress | 28179111 |
| Type | IDs |
|---|---|
| Synonymous | Xrcc-1 |
| Gene |
UniProtKB-ID:
XRCC1_MOUSE,
Q3TGI0_MOUSE
UniprotKB:
Q60596,
Q3TGI0
UniParc:
UPI00005B24E9,
UPI0000020BE9
EMBL:
U02887,
AK168334,
AK168727,
BC085281,
BC055900
Ensembl:
ENSMUSG00000051768
KO:
mmu:22594
|
| Nucleutide sequences |
EMBL-CDS:
AAH85281.1,
AAH55900.1,
BAE40272.1,
AAA93115.1,
BAE40568.1
Ensembl_TRS:
ENSMUST00000063249,
ENSMUST00000205573
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000070995,
ENSMUSP00000146105
RefSeq:
NP_033558.3,
NP_001347098.1,
NP_001347099.1,
NP_001347097.1
|
| Others |
UniRef100:
UniRef100_Q3TGI0,
UniRef100_Q60596
UniRef90:
UniRef90_Q60596
UniRef50:
UniRef50_P18887
UniGene:
Mm.4347
CCDS:
CCDS20955.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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