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225642 Grp

225642

Grp

gastrin releasing peptide

protein-coding

Mus musculus

基因描述

Type Description
Definition gastrin releasing peptide

研究结论

Date Results Publications
2019-10-26 11:02:00 These results establish a spinal gating mechanism for itch that requires sustained repetitive activity of presynaptic GRP neurons and postsynaptic GRP signaling to drive GRPR neuron output 31103358
2019-07-27 10:55:00 Study shows that itch deficits in mice lacking NMB or GRP are non-redundant and Nmb/Grp double KO (DKO) mice displayed additive deficits. Furthermore, both Nmb/Grp and Nmbr/Grpr DKO mice responded normally to a wide array of noxious stimuli. NMB and GRP may transmit discrete itch information and NMBR neurons are an integral part of neural circuits for itch in the spinal cord. 29133874
2019-01-26 12:09:00 Study finds that the combinatorial expression of gastrin releasing peptide and Neurod6 defines midbrain dopaminergic subpopulations with unique features. 30135866
2018-04-28 11:20:00 These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis . 28733141
2018-04-21 10:30:00 Both TRPV1 and GRP are part of a new mesoaccumbal glutamatergic pathway. 27762319

名称对应

Type IDs
Synonymous BLP
Gene
UniProtKB-ID: GRP_MOUSE
UniprotKB: Q8R1I2
UniParc: UPI0000022388
EMBL: AK139345, BC024515, AK133508
Ensembl: ENSMUSG00000024517
KO: mmu:225642
Nucleutide sequences
EMBL-CDS: AAH24515.1, BAE21694.1, BAE23968.1
Ensembl_TRS: ENSMUST00000025395, ENSMUST00000173985
Protein sequencees
Ensembl_PRO: ENSMUSP00000133437, ENSMUSP00000025395
RefSeq: XP_006525949.1, NP_778177.1, XP_006525950.1
Others
UniRef100: UniRef100_Q8R1I2
UniRef90: UniRef90_Q8R1I2
UniRef50: UniRef50_Q8R1I2
UniGene: Mm.20298
CCDS: CCDS29310.1

全选

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研究热度

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