| Type | Description |
|---|---|
| Definition | protein geranylgeranyltransferase type I, beta subunit |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 11:23:00 | Loss of PGGT1B from T cells in mice impairs RHOA function, increasing CD4+ T-cell expression of integrin alpha4beta7 and localization to colon, resulting in increased expression of inflammatory cytokines and colitis. | 31302143 |
| 2018-12-01 12:18:00 | The results showed that the magnitude of long-term potentiation (LTP) was markedly suppressed in hippocampal slices from GGT-haplodeficient mice. Consistent with the synaptic dysfunction, there was a significant decrease in cortical spine density and cognitive function in GGT-haplodeficient mice. | 29406266 |
| 2015-10-31 10:08:00 | This study demonstrated that Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system. | 25330763 |
| 2014-06-21 13:04:00 | A decrease in membrane-associated Rho proteins in aged brain is associated with down-regulation of GGTase-Ibeta. | 24428713 |
| 2013-04-20 14:03:00 | Targeting GGTase-I activates RHOA and leads to increased macrophage reverse cholesterol transport and reduced atherosclerosis development despite a significant increase in inflammation. | 23334894 |
| Type | IDs |
|---|---|
| Synonymous | 2010207C17Rik, 2610100E13, AI451237, AI551093, BGG1, GGT1 |
| Gene |
UniProtKB-ID:
PGTB1_MOUSE
UniprotKB:
Q8BUY9
UniParc:
UPI000002236B
EMBL:
AK081731
Ensembl:
ENSMUSG00000024477
KO:
mmu:225467
|
| Nucleutide sequences |
EMBL-CDS:
BAC38314.1
Ensembl_TRS:
ENSMUST00000236216
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000158214
RefSeq:
XP_036017005.1,
NP_766215.1,
XP_006525929.1,
XP_036017007.1,
XP_036017006.1
|
| Others |
UniRef100:
UniRef100_Q8BUY9
UniRef90:
UniRef90_Q8BUY9
UniRef50:
UniRef50_Q8BUY9
UniGene:
Mm.262096,
Mm.393044
CCDS:
CCDS29230.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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