| Type | Description |
|---|---|
| Definition | formin homology 2 domain containing 3 |
| Date | Results | Publications |
|---|---|---|
| 2018-12-01 11:38:00 | Perinatal KO of Fhod3 in the heart caused juvenile lethality at around day 10 after birth with enlarged hearts composed of severely impaired myofibrils, indicating that Fhod3 is crucial for postnatal heart development. | 29158260 |
| 2018-08-18 10:05:00 | these findings suggest the possibility that Fhod3 contributes to the pathogenesis of cMyBP-C-related cardiomyopathy and that Fhod3 is critically involved in cMyBP-C-mediated regulation of cardiac function via direct interaction. | 29686099 |
| 2017-08-19 10:25:00 | Up regulation of FHOD3 play a crucial role in the pathogenesis of cardiac hypertrophy in mouse model. | 28438902 |
| 2016-07-30 10:11:00 | during embryonic cardiogenesis, Fhod3 functions as the essential reorganizer of actin filaments at the central region of maturating sarcomeres via the actin-binding activity of the FH2 domain | 26848968 |
| 2013-04-06 10:50:00 | Analysis of casein kinase 2 alpha knockout mice showed that phosphorylation by casein kinase 2 is also required for proper targeting of muscle Fhod3 to the myofibrils in embryonic cardiomyocytes in situ. | 23052206 |
| Type | IDs |
|---|---|
| Synonymous | A930009H06Rik, FHOS2, mKIAA1695 |
| Gene |
UniProtKB-ID:
FHOD3_MOUSE
UniprotKB:
Q76LL6
UniParc:
UPI00001D48A5,
UPI00001D4853,
UPI00001D4854,
UPI0000F6E6F4
EMBL:
BC138046,
AB078608,
AK220413,
AB078609,
AB100088
Ensembl:
ENSMUSG00000034295
KO:
mmu:225288
|
| Nucleutide sequences |
EMBL-CDS:
AAI38047.1,
BAC98348.1,
BAC98302.1,
BAD90459.1,
BAC98303.1
Ensembl_TRS:
ENSMUST00000234526,
ENSMUST00000234834,
ENSMUST00000037097
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041361,
ENSMUSP00000157226,
ENSMUSP00000157193
RefSeq:
XP_006525891.1,
NP_780485.2,
XP_006525889.1,
XP_006525893.1,
NP_001276583.1,
NP_001276584.1
|
| Others |
UniRef100:
UniRef100_Q76LL6
UniRef90:
UniRef90_Q76LL6
UniRef50:
UniRef50_Q76LL6
UniGene:
Mm.329322
CCDS:
CCDS89203.1,
CCDS29104.1,
CCDS89202.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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