| Type | Description |
|---|---|
| Definition | retinoblastoma binding protein 8, endonuclease |
| Date | Results | Publications |
|---|---|---|
| 2020-12-26 13:15:00 | CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining. | 32989150 |
| 2020-06-27 10:17:00 | essential for early B cell proliferation and development | 31097467 |
| 2018-06-16 11:24:00 | CtIP enhances long-range resection by BLM-DNA2-RPA. CtIP interacts with and stimulates the activity of the BLM helicase and upregulates DNA2 activity. | 29020620 |
| 2017-12-30 11:58:00 | CtIP is not a tumor suppressor, but has oncogenic properties that can promote tumorigenesis, consistent with its ability to facilitate MMEJ-dependent chromosomal instability. | 27058754 |
| 2017-11-25 15:10:00 | we reveal that reprogramming is associated with high levels of DNA end resection, a critical step in homologous recombination. Moreover, the resection factor CtIP is essential for cell reprogramming and establishment of iPSCs, probably to repair reprogramming-induced DNA damage. | 28065643 |
| Type | IDs |
|---|---|
| Synonymous | 9930104E21Rik, CtIP, RBBP-8, RIM, SAE2 |
| Gene |
UniProtKB-ID:
CTIP_MOUSE
UniprotKB:
Q80YR6
UniParc:
UPI000018CE2B
EMBL:
AC115894,
BC050849,
AC090479
Ensembl:
ENSMUSG00000041238
KO:
mmu:225182
|
| Nucleutide sequences |
EMBL-CDS:
AAH50849.1
Ensembl_TRS:
ENSMUST00000047322,
ENSMUST00000115861
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000046255,
ENSMUSP00000111527
RefSeq:
XP_006525875.1,
NP_001239424.1,
NP_001074692.1,
XP_030106281.1
|
| Others |
UniRef100:
UniRef100_Q80YR6
UniRef90:
UniRef90_Q80YR6
UniRef50:
UniRef50_Q99708
UniGene:
Mm.154275
CCDS:
CCDS37738.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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