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22436 Xdh

22436

Xdh

xanthine dehydrogenase

protein-coding

Mus musculus

基因描述

Type Description
Definition xanthine dehydrogenase

研究结论

Date Results Publications
2020-12-05 13:03:00 Hereditary hemochromatosis disrupts uric acid homeostasis and causes hyperuricemia via altered expression/activity of xanthine oxidase and ABCG2. 32239172
2020-05-23 11:51:00 The miR-218-xanthine oxidoreductase (XOR) pathway may provide a mechanism and treatment option for nonalcoholic steatohepatitis (NASH). 31850710
2020-02-29 11:06:00 After tumor transfer, XO ki mice show strongly increased tumor growth compared to wild type (WT) and XDH ki mice. 31659168
2019-12-28 10:38:00 Hepatocyte XOR activity is a critical determinant of systemic uric acid homeostasis. Deletion of hepatocyte Xdh is sufficient to prevent systemic hyperuricemia of obesity, and neither prevention nor correction of hyperuricemia improves insulin resistance/dyslipidemia in obesity. 30936145
2019-12-21 11:29:00 the results identify Xdh gene as one of the major targets of DEHP in newborn ovaries and that the consequent increased level of is possibly responsible for the increment of apoptosis and primordial follicle assembly impairment. 30938853

名称对应

Type IDs
Synonymous XO, Xor, Xox-1, Xox1
Gene
UniProtKB-ID: XDH_MOUSE, Q9CVF2_MOUSE
UniprotKB: Q00519, Q9CVF2
UniParc: UPI0000022221, UPI00000E6E7B
EMBL: X75129, AK008517, X75122, X75150, X75138, X75131, X75141, X75127, X75145, X75153, X75135, X75134, X75146, X75120, X75149, X75154, X75136, X75147, AC159187, X75142, X75144, X75140, X75123, X75130, X75148, X75125, X75126, X75119, X75151, CT025731, X75121, X75139, X75152, X75128, X75132, X75133, X75124, X62932, X75143, X75137
Ensembl: ENSMUSG00000024066
KO: mmu:22436
Nucleutide sequences
EMBL-CDS: CAA44705.1, CAA52997.1, BAB25715.1
Ensembl_TRS: ENSMUST00000024866
Protein sequencees
Ensembl_PRO: ENSMUSP00000024866
RefSeq: XP_011244683.1, NP_035853.2
Others
UniRef100: UniRef100_Q00519
UniRef90: UniRef90_Q00519
UniRef50: UniRef50_P47989
UniGene: Mm.11223
CCDS: CCDS28967.1

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