| Type | Description |
|---|---|
| Definition | Werner syndrome RecQ like helicase |
| Date | Results | Publications |
|---|---|---|
| 2018-06-30 12:12:00 | These results suggest that a great number of endoplasmic reticulum (ER) gene products are regulated at the post-transcriptional level in the liver of Wrn mutant mice exhibiting an ER stress response. | 29494634 |
| 2016-09-10 11:26:00 | A mislocalization of the Wrn mutant protein in the liver endoplasmic reticulum fraction increased oxidative stress in that cellular compartment. Vitamin C reversed this oxidative stress. | 26521679 |
| 2016-06-04 10:41:00 | The deleterious effects of the helicase-deficient Wrn protein are mediated by the dysfunction of several cellular organelles. | 26447695 |
| 2015-10-31 11:27:00 | Data suggest that, in the context of Wrn deficiency-related telomere dysfunction, loss of p16Ink4a function could prevent cells from senescence. | 22754337 |
| 2015-04-11 12:16:00 | The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers. | 24608430 |
| Type | IDs |
|---|---|
| Synonymous | AI846146 |
| Gene |
UniProtKB-ID:
WRN_MOUSE,
Q3TB25_MOUSE,
Q8BWH5_MOUSE
UniprotKB:
O09053,
Q3TB25,
Q8BWH5
UniParc:
UPI00005B27D5,
UPI0000023808,
UPI00000EA7C3
EMBL:
D86527,
AC115809,
AF241636,
BC060700,
AK171490,
AC153789,
D86526,
AK052466,
BC050921,
AF091215,
AF091216
Ensembl:
ENSMUSG00000031583
KO:
mmu:22427
|
| Nucleutide sequences |
EMBL-CDS:
AAF64490.1,
BAA20270.1,
AAH60700.1,
AAC78077.1,
AAC72359.1,
AAH50921.1,
BAA20269.1,
BAE42489.1,
BAC35005.1
Ensembl_TRS:
ENSMUST00000033990,
ENSMUST00000033991
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033990,
ENSMUSP00000033991
RefSeq:
XP_006509156.1,
XP_017168151.1,
XP_036009773.1,
NP_001116294.1,
NP_035851.3,
XP_006509154.1
|
| Others |
UniRef100:
UniRef100_O09053
UniRef90:
UniRef90_O09053
UniRef50:
UniRef50_Q14191
UniGene:
Mm.228805
CCDS:
CCDS22229.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员