| Type | Description |
|---|---|
| Definition | adenylate cyclase 5 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 12:02:00 | findings demonstrate a unique role for AC5 in modulation of L-type Ca2+ channel activity and vascular reactivity during acute hyperglycemia and diabetes. | 31162142 |
| 2019-09-14 13:19:00 | 90 is the most potent AC5 inhibitor, as exhibited by its IC50 value for AC5 inhibition, which was 5 times lower than the next most potent AC5 inhibitor. C90 reduced cAMP in response to forskolin in wild type mice by 42%, but no longer reduced cAMP in response to forskolin in mice with disruption of AC5, indicating that the mechanism of C90 was specific for AC5 inhibition | 29800555 |
| 2018-12-22 11:57:00 | AC5 contributes importantly to increased renal cAMP levels and cyst growth in Pkd2 mutant mice, and inhibition of AC5 may be beneficial in the treatment of polycystic kidney disease. | 29042084 |
| 2018-07-28 10:13:00 | AC5 mutation produces autistic-like symptoms through the upregulation of mGluR5 functions in the dorsal striatum and that the dorsal striatum regulated by AC5 is a neural correlate responsible for core Autism spectrum disorders symptoms | 27878759 |
| 2018-07-21 11:57:00 | Results show that both ATP and Gsalpha binding have significant effects on the structure and flexibility of adenylyl cyclase. New data on ATP bound to AC5 in the absence of Gsalpha notably help to explain how Gsalpha binding enhances enzyme activity and could aid product release. Simulations also suggest a possible coupling between ATP binding and interactions with the inhibitory G-protein subunit Galphai. | 29694437 |
| Type | IDs |
|---|---|
| Synonymous | AW121902, Ac5 |
| Gene |
UniProtKB-ID:
ADCY5_MOUSE
UniprotKB:
P84309
UniParc:
UPI00001E37D7,
UPI0000EADF09
EMBL:
BC090846,
AK160942,
BC035550,
AK147649
Ensembl:
ENSMUSG00000022840
KO:
mmu:224129
|
| Nucleutide sequences |
EMBL-CDS:
AAH90846.1,
BAE28048.1,
BAE36104.1
Ensembl_TRS:
ENSMUST00000114913
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000110563
RefSeq:
XP_030104945.1,
NP_001012783.3
|
| Others |
UniRef100:
UniRef100_P84309
UniRef90:
UniRef90_P84309
UniRef50:
UniRef50_Q03343
UniGene:
Mm.41137
CCDS:
CCDS37322.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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