| Type | Description |
|---|---|
| Definition | cellular communication network factor 5 |
| Date | Results | Publications |
|---|---|---|
| 2019-05-11 12:55:00 | these data suggest that down-regulation of CCN5 is associated with fibrotic deformation of Retinal pigment epithelium (RPE) under pathological conditions and that restoration of the CCN5 level effectively promotes recovery of deformed RPE. | 30571728 |
| 2019-04-27 12:10:00 | Knockout (KO) of CCN5, which encodes a matricellular protein, caused mild obesity. The CCN5 KO mice also exhibited mild diabetes characterized by high fasting glucose levels and impaired insulin and glucose tolerances. Cardiac hypertrophy, ectopic lipid accumulation, and impaired lipid metabolism in hearts were observed in CCN5 KO. | 30485307 |
| 2018-11-10 10:55:00 | WISP2 is a novel secreted adipokine, most highly expressed in the subcutaneous adipose tissue and primarily in mesenchymal precursor cells. WISP2 is, to the best of our knowledge, the first identified endogenous and secreted autocrine/endocrine regulator of adipose tissue and heart/muscle cellularity and growth. | 28240264 |
| 2017-08-05 11:03:00 | Insulin-like growth factor (IGF)-1 elicited clear stimulation of WNT1 inducible signaling pathway protein 2 (CCN5/WISP2) mRNA and protein levels in cultured islets. | 27863006 |
| 2014-06-21 10:09:00 | Data suggest that CCN5, minimally expressed in unstimulated islet beta-cells, is strongly and directly induced by Igf1 (insulin-like growth factor I); overexpression of CCN5 stimulates cell proliferation and inhibits streptozotocin-induced apoptosis. | 24552398 |
| Type | IDs |
|---|---|
| Synonymous | Crgr4, Ctgfl, Rcop1, Wisp2 |
| Gene |
UniProtKB-ID:
CCN5_MOUSE,
A2AHD1_MOUSE
UniprotKB:
Q9Z0G4,
A2AHD1
UniParc:
UPI0000192FD9,
UPI000002950A
EMBL:
AF100778,
AF126063,
BC032877,
AL731698
Ensembl:
ENSMUSG00000027656
KO:
mmu:22403
|
| Nucleutide sequences |
EMBL-CDS:
AAC96320.1,
AAH32877.1,
AAD18058.1
Ensembl_TRS:
ENSMUST00000029188
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000029188
RefSeq:
NP_058569.2,
XP_006499232.1
|
| Others |
UniRef100:
UniRef100_Q9Z0G4,
UniRef100_A2AHD1
UniRef90:
UniRef90_Q9Z0G4
UniRef50:
UniRef50_Q9JHC6
UniGene:
Mm.13828
CCDS:
CCDS17016.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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