| Type | Description |
|---|---|
| Definition | phosphatidylinositol 4-kinase alpha |
| Date | Results | Publications |
|---|---|---|
| 2019-11-02 13:25:00 | These studies define a role for PI4KA in myelin formation primarily affecting metabolism of key phospholipids and the actin cytoskeleton. | 29874576 |
| 2019-06-01 10:17:00 | Mutation of Pi4ka found to promote myeloid and erythroid dysfunction. Subsequent validation experiments showed that targeted inactivation of the Pi4ka catalytic domain or reduction in mRNA expression inhibited myeloid and erythroid cell differentiation in vitro and promoted anemia in vivo | 29386109 |
| 2014-04-26 11:40:00 | PI4KA is essential for the maintenance of plasma membrane phosphatidylinositol 4,5-bisphosphate pools but only during strong stimulation of receptors coupled to phospholipase C activation. | 24415756 |
| 2013-02-23 11:24:00 | It was shown that PI4KIIIalpha was targeted to the plasma membrane as part of an evolutionarily conserved complex containing Efr3/rolling blackout, which was found to be a palmitoylated peripheral membrane protein. | 23229899 |
| 2010-01-21 00:00:00 | Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons. | 19581584 |
| Type | IDs |
|---|---|
| Synonymous | Pik4ca |
| Gene |
UniProtKB-ID:
PI4KA_MOUSE,
A0A140T8I9_MOUSE,
A0A1S6GWJ7_MOUSE
UniprotKB:
E9Q3L2,
A0A140T8I9,
A0A1S6GWJ7
UniParc:
UPI0003D77632,
UPI00015DE9D1
EMBL:
AC110573,
BC049252,
BC055479,
AK136942,
KY499708,
BC075629
Ensembl:
ENSMUSG00000041720
KO:
mmu:224020
|
| Nucleutide sequences |
EMBL-CDS:
AAH75629.1,
AAH55479.1,
BAE23184.1,
AAH49252.1,
AQS27629.1
Ensembl_TRS:
ENSMUST00000036161,
ENSMUST00000232232
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000156049,
ENSMUSP00000036162
RefSeq:
NP_001360884.1,
XP_030104929.1,
NP_001001983.2,
XP_006522099.1,
XP_006522100.1
|
| Others |
UniRef100:
UniRef100_E9Q3L2
UniRef90:
UniRef90_P42356
UniRef50:
UniRef50_P42356
UniGene:
Mm.5718
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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