| Type | Description |
|---|---|
| Definition | vaccinia related kinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 10:08:00 | Ginsenoside Rg3 upregulate VRK1 expression and P53BP1 foci formation in response to DNA damage. | 31629252 |
| 2019-10-26 12:46:00 | Together, these studies of the partial KO Vrk1 mice reveal that even moderately reduced levels of Vrk1 expression result in minor neurological impairment and indicate new neuronal pathways likely involving VRK1. | 30050127 |
| 2018-06-16 12:02:00 | VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose. | 28911860 |
| 2015-03-28 11:08:00 | VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP). APP overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP-dependent mechanism. | 25609612 |
| 2013-03-02 10:57:00 | Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system. | 22741057 |
| Type | IDs |
|---|---|
| Synonymous | 51PK |
| Gene |
UniProtKB-ID:
VRK1_MOUSE,
Q3UWH3_MOUSE
UniprotKB:
Q80X41,
Q3UWH3
UniParc:
UPI00000E7E61,
UPI0000029A13,
UPI0000029A14,
UPI00000EA01B
EMBL:
AK032344,
AF080252,
BC016676,
AK136352,
AK088230,
AF080253,
AK088674
Ensembl:
ENSMUSG00000021115
KO:
mmu:22367
|
| Nucleutide sequences |
EMBL-CDS:
AAC29497.1,
AAH16676.1,
BAC40497.1,
BAC27825.1,
AAC29496.1,
BAC40225.1,
BAE22942.1
Ensembl_TRS:
ENSMUST00000021539,
ENSMUST00000072040,
ENSMUST00000220629,
ENSMUST00000085026
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000082101,
ENSMUSP00000152109,
ENSMUSP00000071922,
ENSMUSP00000021539
RefSeq:
XP_006515873.1,
XP_011242406.1,
XP_030102547.1,
XP_030102556.1,
NP_001351296.1,
XP_030102553.1,
XP_030102554.1,
XP_030102545.1,
XP_030102546.1,
XP_036013279.1,
XP_030102550.1,
XP_036013278.1,
XP_017170534.1,
XP_036013276.1,
XP_030102551.1,
XP_030102548.1,
XP_036013274.1,
XP_006515874.1,
NP_001351297.1,
XP_030102552.1,
NP_001351294.1,
NP_001025014.1,
XP_036013275.1,
XP_030102549.1,
NP_035835.1,
XP_006515872.1,
NP_001025015.1,
XP_036013277.1
|
| Others |
UniRef100:
UniRef100_Q80X41,
UniRef100_Q3UWH3
UniRef90:
UniRef90_Q80X41
UniRef50:
UniRef50_Q80X41
UniGene:
Mm.2981
CCDS:
CCDS26158.1,
CCDS36551.1,
CCDS26157.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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