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22256 Ung

22256

Ung

uracil DNA glycosylase

protein-coding

Mus musculus

基因描述

Type Description
Definition uracil DNA glycosylase

研究结论

Date Results Publications
2021-01-23 13:04:00 Interplay between UNG and AID governs intratumoral heterogeneity in mature B cell lymphoma. 33362210
2020-01-18 12:53:00 during AID-induced class switch recombination, UNG in association with recombination factors may facilitate the stabilization of the S-S synapse to facilitate efficient recombination. 29735979
2019-11-30 11:36:00 We identified a distinct UNG1 isoform variant that is targeted to the cell nucleus where it supports antibody class switching and repairs genomic uracil. We propose that the nuclear UNG1 variant, which in contrast to UNG2 lacks a PCNA-binding motif, may be specialized to act on ssDNA through its ability to bind RPA 30838409
2019-02-23 12:35:00 we showed that SMUG1 efficiently prevent genomic uracil accumulation, even in the presence of UNG, and identified mutational signatures associated with combined UNG and SMUG1 deficiency. 28775312
2017-08-19 11:52:00 Pms2/Mlh1 and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases. 28283534

名称对应

Type IDs
Synonymous UNG1, UNG2
Gene
UniProtKB-ID: UNG_MOUSE, Q791V7_MOUSE
UniprotKB: P97931, Q791V7
UniParc: UPI0000000888, UPI0000023251
EMBL: AK168709, BC011039, U55041, X99018, AK146178, AF174485, AK168785, Y08975, BC052853, CH466529, U55040
Ensembl: ENSMUSG00000029591
KO: mmu:22256
Nucleutide sequences
EMBL-CDS: AAH52853.1, AAF76936.1, CAA70168.1, BAE26956.1, AAC53197.1, AAH11039.1, AAB39511.1, EDL19920.1, CAA67489.1, BAE40551.1, AAF76937.1, BAE40619.1
Ensembl_TRS: ENSMUST00000102584, ENSMUST00000031587
Protein sequencees
Ensembl_PRO: ENSMUSP00000099644, ENSMUSP00000031587
RefSeq: NP_001035781.1, NP_035807.2, XP_006530347.1
Others
UniRef100: UniRef100_P97931, UniRef100_Q791V7
UniRef90: UniRef90_P97931, UniRef90_Q5BK44
UniRef50: UniRef50_P97931, UniRef50_P13051
UniGene: Mm.1393
CCDS: CCDS19560.1, CCDS39221.1

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