| Type | Description |
|---|---|
| Definition | uromodulin |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 13:55:00 | Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis. | 31444371 |
| 2019-09-21 11:17:00 | A biological link between salt stress in the loop of Henle and interactions between Umod and heat-shock proteins. | 30216136 |
| 2019-09-21 11:15:00 | Taken together, our data suggest that interstitial THP positively regulates mononuclear phagocyte number, plasticity, and phagocytic activity. In addition to the effect of THP on the epithelium and granulopoiesis, this new immunomodulatory role could explain the protection conferred by THP during AKI. | 29180395 |
| 2019-09-14 10:21:00 | THP deficiency can cause progressive disturbances in renal functions via initially NKCC2 dysfunction and later compensatory responses, resulting in prolonged activation of the renin-angiotensin-aldosterone axis and hyperuricemia. | 29357410 |
| 2019-07-02 09:32:00 | Our data support a role for uromodulin in the functional heterogeneity along the DCT: Umod-/- mice show less pNCC in DCT1 and increased pNCC in DCT2, paralleled by an expansion of DCT2. When exposed to chronic distal salt loading (furosemide), Umod-/- mice show a severely blunted capacity to increase NCC phosphorylation and lack the capacity to upregulate the DCT1 and DCT2 areas, compared with Umodthorn/thorn mice. | 30007527 |
| Type | IDs |
|---|---|
| Synonymous | THP, Urehd1, urehr4 |
| Gene |
UniProtKB-ID:
UROM_MOUSE
UniprotKB:
Q91X17
UniParc:
UPI000002364B
EMBL:
AK164688,
L33406,
AK165507,
AK085460,
BC012973,
AK144065
Ensembl:
ENSMUSG00000030963
KO:
mmu:22242
|
| Nucleutide sequences |
EMBL-CDS:
BAE38225.1,
BAC39452.1,
AAH12973.1,
AAA73896.1,
BAE37877.1,
BAE25681.1
Ensembl_TRS:
ENSMUST00000209095,
ENSMUST00000033263
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033263,
ENSMUSP00000146652
RefSeq:
NP_001265534.1,
NP_033496.1
|
| Others |
UniRef100:
UniRef100_Q91X17
UniRef90:
UniRef90_Q91X17
UniRef50:
UniRef50_P07911
UniGene:
Mm.10826
CCDS:
CCDS21780.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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