| Type | Description |
|---|---|
| Definition | ubiquitin specific peptidase 5 (isopeptidase T) |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 11:14:00 | dysregulation of USP5 SUMOylation after peripheral nerve injury may contribute to the well described alteration in Cav3.2 channel activity | 31455361 |
| 2019-01-12 11:19:00 | USP5 mediated dysregulation of Cav3.2 channel activity does not exhibit sex differences, and potential therapeutics targeting this interaction should be effective in both male and female subjects. | 30340616 |
| 2018-09-08 11:36:00 | identify interleukin-1 beta as an upstream trigger for the upregulation of interactions between USP5 and Cav3.2 channels in the pain pathway | 28741432 |
| 2017-12-02 12:15:00 | Sensitization was relieved by pharmacological block of TRPV1 afferents, but not of myelinated neurons. In spinal cord slice recordings, we could optogenetically trigger an activity-dependent potentiation of presynaptic neurotransmission in the spinal dorsal horn that relied on Cav3.2 channel activity. This neuronal-activity-induced USP5 upregulation may underlie a protective, transient sensitization of the pain pathway. | 27974205 |
| 2016-02-27 11:41:00 | Suramin and Cav3.2/USP5 Tat-disruptor peptides were also tested in models of diabetic neuropathy and visceral pain, and provided remarkable protection | 25889575 |
| Type | IDs |
|---|---|
| Synonymous | AA407472, ISOT, ISOT-1, Ucht |
| Gene |
UniProtKB-ID:
UBP5_MOUSE,
Q3U4W8_MOUSE
UniprotKB:
P56399,
Q3U4W8
UniParc:
UPI000002681C,
UPI00001F436D
EMBL:
AK154008,
BC066993,
AC142254,
AC002397
Ensembl:
ENSMUSG00000038429
KO:
mmu:22225
|
| Nucleutide sequences |
EMBL-CDS:
AAH66993.1,
AAC36015.1,
BAE32312.1
Ensembl_TRS:
ENSMUST00000047510,
ENSMUST00000122110
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041299,
ENSMUSP00000114000
RefSeq:
XP_030111177.1,
XP_030111178.1,
NP_001313523.1,
XP_006505979.1,
XP_036021916.1,
NP_038728.1
|
| Others |
UniRef100:
UniRef100_Q3U4W8,
UniRef100_P56399
UniRef90:
UniRef90_F7CT78,
UniRef90_P56399
UniRef50:
UniRef50_P56399
UniGene:
Mm.3571
CCDS:
CCDS20531.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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