| Type | Description |
|---|---|
| Definition | TYRO protein tyrosine kinase binding protein |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 14:51:00 | The findings reveal an important function for DAP12 in Th1 cells and a new mechanism to recruit effector T cells to sites of inflammation. | 31757864 |
| 2019-12-07 10:59:00 | Results suggest that TYROBP/DAP12 could represent a novel therapeutic target to slow, arrest, or prevent the development of sporadic LOAD. These data establish that the network pathology observed in postmortem human LOAD brain can be faithfully recapitulated in the brain of a genetically manipulated mouse. | 30283032 |
| 2019-02-23 11:02:00 | High DAP12 expression is associated with Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases. | 29272492 |
| 2019-01-15 15:01:00 | Data (including data from studies conducted with cells from knockout mice) suggest that Cd300e on the surface of monocytes or mast cells recognizes the ligand sphingomyelin and thereby regulates non-classical and intermediate immunologic functions through FcRgamma and DAP12. (Cd300e = CD300 antigen like family member E; FcRgamma = Fc receptor subunit gamma; DAP12 = DNAX-activation protein-12) | 29358324 |
| 2018-02-03 10:22:00 | We identified modulatory effects of TYROBP deficiency on the level of phosphorylation of TAU that was accompanied by a reduction in the severity of neuritic dystrophy. TYROBP deficiency also altered the expression of several AD related genes, including Cd33. Electrophysiological abnormalities and learning behavior deficits associated with APP/PSEN1 transgenes were greatly attenuated on a Tyrobp-null background. | 28612290 |
| Type | IDs |
|---|---|
| Synonymous | DAP12, KARAP, Ly83 |
| Gene |
UniProtKB-ID:
TYOBP_MOUSE,
Q3U419_MOUSE
UniprotKB:
O54885,
Q3U419
UniParc:
UPI0000023532
EMBL:
BC056450,
AF024637,
AF077829,
AK154480
Ensembl:
ENSMUSG00000030579
KO:
mmu:22177
|
| Nucleutide sequences |
EMBL-CDS:
AAD09438.1,
AAC95529.1,
AAH56450.1,
BAE32616.1
Ensembl_TRS:
ENSMUST00000032800
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000032800
RefSeq:
NP_035792.1
|
| Others |
UniRef100:
UniRef100_O54885
UniRef90:
UniRef90_O54885
UniRef50:
UniRef50_O43914
UniGene:
Mm.46301
CCDS:
CCDS21089.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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