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2215 FCGR3B

2215

FCGR3B

Fc fragment of IgG receptor IIIb

protein-coding

Homo sapiens

基因描述

Type Description
Definition Fc fragment of IgG receptor IIIb

研究结论

Date Results Publications
2020-09-12 16:02:00 Primary structure of human neutrophil antigens 1a and 1b. 32072650
2020-04-18 12:35:00 CCL3L1 and FCGR3B copy number variants may not be involved in susceptibility to ankylosing spondylitis risk in the Algerian population. 31433132
2019-11-30 11:59:00 Study identified FcgammaRIIIb specific Asn45 glycosylation and an allelic effect on glycosylation at Asn162. FcgammaRIIIb specific glycosylation allows for assignment of FcgammaRIIIb alleles and relative copy number of the two alleles where DNA/RNA is not available. The types of structures found to be elevated at Asn162 in the NA2 allele are found to destabilize the Fc:FcgammaRIII interaction resulting in a faster diss... 30559323
2019-10-26 12:40:00 Study data confirm FcgammaRIIIb as a negative regulator of neutrophil antibody-dependent cellular cytotoxicity toward tumor cells and a potential target for enhancing tumor cell destruction by neutrophils. 30761158
2019-03-09 11:43:00 Collectively, these results indicate that the amino acid substitution Ala78Asp resulting in the HNA-1c allotype leads to higher affinity toward human IgG, enhancement of neutrophil activation, and possibly effective clearance of malaria by intracellular reactive oxygen species. 29784860

名称对应

Type IDs
Synonymous CD16, CD16A, CD16b, FCG3, FCGR3, FCGR3A, FCR-10, FCRIII, FCRIIIb
Gene
UniProtKB-ID: FCG3B_HUMAN, A0A087WZR4_HUMAN, A0A087WU90_HUMAN, A0A3B3ISU3_HUMAN
UniprotKB: O75015, A0A087WZR4, A0A087WU90, A0A3B3ISU3
UniParc: UPI00027CCADE, UPI0000D62032, UPI000012A58A, UPI00027CCADD
EMBL: Z46223, X07934, J04162, AL451067, X16863, M24854, AJ581669
Ensembl: ENSG00000162747
KO: hsa:2215
Nucleutide sequences
EMBL-CDS: CAA30758.1, AAA53507.1, CAA34753.1, CAA86296.1, AAA35881.1, CAE46408.1
Ensembl_TRS: ENST00000294800, ENST00000367964, ENST00000613418, ENST00000614870, ENST00000650385
Protein sequencees
Ensembl_PRO: ENSP00000294800, ENSP00000356941, ENSP00000482838, ENSP00000478466, ENSP00000497461
RefSeq: NP_001257965.1, NP_000561.3, NP_001257964.2, NP_001257966.1, NP_001231682.2
Others
UniRef100: UniRef100_A0A3B3ISU3, UniRef100_O75015, UniRef100_A0A087WU90
UniRef90: UniRef90_A0A2I3TKZ4, UniRef90_O75015
UniRef50: UniRef50_O75015, UniRef50_A0A2I3TKZ4
UniGene: Hs.372679, Hs.694258, Hs.736230
CCDS: CCDS58040.1, CCDS41433.1

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