| Type | Description |
|---|---|
| Definition | LEM domain containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:29:00 | Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure. | 32271860 |
| 2021-02-20 13:28:00 | Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide | 32085595 |
| 2020-07-11 10:25:00 | LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation | 32494070 |
| 2020-05-16 10:46:00 | LEMD2 is required for recruitment of the ESCRT-III membrane repair machinery to ruptures; however, neither LEMD2 nor ESCRT-III is required to repair ruptures. These results reveal a new role for BAF in the response to and repair of nuclear ruptures. | 31147383 |
| 2020-02-08 12:24:00 | a recurrent de novo mutation in LEMD2 causes a nuclear envelopathy whose prognosis in adolescence is relatively good in comparison to that of classical Hutchinson-Gilford progeria syndrome | 30905398 |
| Type | IDs |
|---|---|
| Synonymous | CTRCT42, LEM2, NET25, dJ482C21.1 |
| Gene |
UniProtKB-ID:
LEMD2_HUMAN,
A0A024RCZ1_HUMAN
UniprotKB:
Q8NC56,
A0A024RCZ1
UniParc:
UPI000006DAEA,
UPI00018E24EC
EMBL:
CH471081,
BC051803,
AL158049,
AK301083,
AK074959
Ensembl:
ENSG00000161904
KO:
hsa:221496
|
| Nucleutide sequences |
EMBL-CDS:
BAG62687.1,
BAC11316.1,
AAH51803.1,
EAX03750.1,
EAX03751.1
Gene_ORFName:
hCG_41257
Ensembl_TRS:
ENST00000293760,
ENST00000508327,
ENST00000614475
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000293760,
ENSP00000421704,
ENSP00000478539
RefSeq:
NP_001335638.1,
NP_851853.1,
NP_001335639.1,
NP_001137416.1,
XP_016865926.1
|
| Others |
UniRef100:
UniRef100_Q8NC56
UniRef90:
UniRef90_Q8NC56
UniRef50:
UniRef50_Q8NC56
UniGene:
Hs.444845
CCDS:
CCDS4785.1,
CCDS47411.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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