| Type | Description |
|---|---|
| Definition | tubulin, alpha 1A |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:33:00 | A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse. | 33137126 |
| 2020-08-01 11:06:00 | Tubulin-specific chaperon E knockdown induces the accumulation of inert alpha-tubulin that cannot form microtubules in the cell body. | 31699369 |
| 2020-01-11 12:14:00 | Study shows that loss of Tubb2a or Tubb2b does not impair survival but does lead to relatively mild cortical malformation phenotypes. In contrast, loss of Tuba1a is perinatal lethal and leads to significant forebrain dysmorphology. The ability of the mouse to survive in the absence of some tubulin genes known to cause disease in humans suggests future intervention strategies for these devastating tubulinopathy diseases. | 31386652 |
| 2019-07-06 12:44:00 | In this study, we demonstrate that missense mutations affecting arginine at position 402 (R402) of TUBA1A alpha-tubulin selectively impair dynein motor activity and severely and dominantly disrupt cortical neuronal migration. | 30517687 |
| 2019-03-02 12:09:00 | Transgenic mdx mice expressing the short dystrophin isoform Dp116 served as a negative control. All mini- and micro-dystrophins restored elevated detyrosinated alpha-tubulin and microtubule density of mdx muscle to values not different from C57BL/10, however, only mini-dystrophins restored the transverse component of the microtubule lattice back to C57BL/10. | 29618008 |
| Type | IDs |
|---|---|
| Synonymous | Tuba-1, Tuba1 |
| Gene |
UniProtKB-ID:
TBA1A_MOUSE
UniprotKB:
P68369
UniParc:
UPI0000000DB2
EMBL:
M13445,
BC083345,
AK077529,
BC056169,
AK167687,
M28729,
AK164335,
AK145404,
BC085256,
BC083343,
AK169610,
AK168762,
BC083344,
AK146983
Ensembl:
ENSMUSG00000072235
KO:
mmu:22142
|
| Nucleutide sequences |
EMBL-CDS:
BAC36848.1,
AAH83343.1,
AAA40506.1,
AAH83345.1,
BAE39734.1,
BAE40598.1,
BAE27586.1,
AAH83344.1,
BAE26417.1,
AAH85256.1,
AAA40499.1,
BAE41258.1,
BAE37745.1,
AAH56169.1
Ensembl_TRS:
ENSMUST00000097014
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000094778
RefSeq:
NP_035783.1
|
| Others |
UniRef100:
UniRef100_Q71U36
UniRef90:
UniRef90_Q71U36
UniRef50:
UniRef50_Q71U36
UniGene:
Mm.405359
CCDS:
CCDS37196.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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