| Type | Description |
|---|---|
| Definition | zinc finger containing ubiquitin peptidase 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 12:28:00 | ZUFSP is recruited to and regulates K63-Ub conjugates at genotoxic stress sites, promoting chromosome stability upon replication stress in a manner dependent on its catalytic activity. | 29576528 |
| 2019-01-19 12:28:00 | Identify two ubiquitin binding domains in ZUFSP: a ZHA (ZUFSP helical arm) that binds to the distal ubiquitin and an atypical UBZ domain in ZUFSP that binds to polyubiquitin. Importantly, both domains are essential for ZUFSP to selectively cleave K63-linked polyubiquitin. | 29576527 |
| 2018-05-12 10:57:00 | ZUFSP,the singular human member of this family, which contains multiple ubiquitin-binding domains responsible for the specific action on K63-linked chains. | 29476094 |
| 2018-03-05 14:48:00 | ZUFSP (ZUP1) is a K63-specific deubiquitinating enzyme that is distantly related to proteases for the ubiquitin-like modifiers Ufm1 and Atg8. ZUFSP does not have any activity on these modifiers. ZUFSP specifically cleaves long K63-linked poly-ubiquitin chains in an ""endo"" mode, i.e. cleavage takes place in the middle of a chain rather than by removing the terminal ubiquitin from a chain. | 29476094 |
| Type | IDs |
|---|---|
| Synonymous | C6orf113, DUB, ZUFSP |
| Gene |
UniProtKB-ID:
ZUP1_HUMAN,
A0A0S2Z644_HUMAN
UniprotKB:
Q96AP4,
A0A0S2Z644
UniParc:
UPI000006E8C6,
UPI00001BDA28
EMBL:
BX537872,
AK054582,
BC016879,
AL132795,
CH471051,
KU178892,
BC015420
Ensembl:
ENSG00000153975
KO:
hsa:221302
|
| Nucleutide sequences |
EMBL-CDS:
CAD97873.1,
BAB70765.1,
AAH15420.1,
AAH16879.1,
EAW48218.1,
ALQ34350.1
Gene_ORFName:
hCG_21762
Ensembl_TRS:
ENST00000368576
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000357565
RefSeq:
NP_001348120.1,
NP_659499.2,
NP_001348119.1,
NP_001348118.1
|
| Others |
UniRef100:
UniRef100_Q96AP4
UniRef90:
UniRef90_Q96AP4
UniRef50:
UniRef50_Q96AP4
UniGene:
Hs.29857
CCDS:
CCDS5110.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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