| Type | Description |
|---|---|
| Definition | Fc fragment of IgG receptor IIb |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:12:00 | Human Fcgamma-receptor IIb modulates pathogen-specific versus self-reactive antibody responses in lyme arthritis. | 32613944 |
| 2020-10-31 13:13:00 | The Complex Association of FcgammaRIIb With Autoimmune Susceptibility. | 31681256 |
| 2020-04-04 13:03:00 | Study in syngeneic mouse glioblastoma (GBM) model, human GBM samples, and cancer-immune cell co-culture revealed that IGFBP2-promoted immunosuppression associated with its induction of the mesenchymal feature of GBM cells and the inhibitory phosphorylated FcgammaRIIB of GBM exposed immune cells. Inhibition of IGFBP2 relieved immunosuppression by increasing CD8+ T and CD19+ B cells and decreasing CD163+ M2 macrophages. | 31560714 |
| 2020-02-08 11:37:00 | The authors identified a subset of effector CD8(+) T cells that expressed the inhibitory fragment crystallizable receptor FcgammaRIIB following activation and multiple rounds of division. these findings demonstrate a cell-intrinsic coinhibitory function of FcgammaRIIB in regulating CD8(+) T cell immunity. | 31940267 |
| 2020-02-08 10:30:00 | I232T substitution reduces in situ two-dimensional binding affinities and association rates of FcgammaRIIB to interact with its ligands, IgG1, IgG2 and IgG3 by three to four folds. This allosteric regulation by a single nucleotide polymorphism provides an intrinsic molecular mechanism for the functional loss of FcgammaRIIB-I232T in systemic lupus erythematosus patients. | 31343409 |
| Type | IDs |
|---|---|
| Synonymous | CD32, CD32B, FCG2, FCGR2, FCGR2C, FcRII-c, IGFR2 |
| Gene |
UniProtKB-ID:
FCG2B_HUMAN
UniprotKB:
P31994
UniParc:
UPI000002A985,
UPI000016B51E,
UPI000002A984,
UPI0000001600,
UPI000016B51D
EMBL:
AL359541,
M31933,
U87566,
U87577,
M31934,
U87571,
U87565,
U87562,
U87568,
CR407635,
U87561,
M31935,
AB050934,
U87572,
X17653,
U87564,
U87563,
X52473,
U87570,
U87576,
U87574,
U87575,
U87560,
BC031992,
U87573,
U87569,
BC146678,
U87567
Ensembl:
ENSG00000072694
KO:
hsa:2213
|
| Nucleutide sequences |
EMBL-CDS:
CAA35644.1,
AAA35842.1,
AAD00634.1,
AAD00644.1,
CAG28563.1,
CAA36713.1,
BAB92093.1,
AAD00631.1,
CAA35645.1,
AAD00640.1,
AAD00638.1,
AAD00627.1,
AAA35841.1,
AAH31992.1,
AAD00637.1,
AAI46679.1,
AAD00635.1,
AAD00632.1,
AAD00639.1,
AAD00633.1,
AAD00629.1,
AAD00630.1,
AAD00643.1,
AAD00636.1,
AAD00642.1,
AAD00641.1,
AAD00628.1,
AAA35843.1
Ensembl_TRS:
ENST00000236937,
ENST00000367961,
ENST00000358671
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000236937,
ENSP00000351497,
ENSP00000356938
RefSeq:
NP_001372931.1,
NP_001372934.1,
NP_001177757.1,
NP_001372932.1,
XP_024309811.1,
NP_001372930.1,
NP_001372935.1,
NP_001372933.1,
NP_001372929.1,
NP_003992.3,
NP_001002274.1,
NP_001002275.1,
NP_001002273.1,
XP_016856159.1,
XP_024309815.1
|
| Others |
UniRef100:
UniRef100_P31994
UniRef90:
UniRef90_P31994
UniRef50:
UniRef50_P31994
UniGene:
Hs.654395
CCDS:
CCDS30925.1,
CCDS53414.1,
CCDS30924.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员