| Type | Description |
|---|---|
| Definition | tuberous sclerosis 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-13 13:07:00 | Loss of TSC2 expression is associated with focal segmental glomerulosclerosis and progressive renal failure. | 32191726 |
| 2020-05-09 11:08:00 | selective hematological parameters and glomerular filtration rate were further reduced significantly in irradiated Tsc2+/- mice. Tsc2 protein, tuberin in irradiated mice, however, remains at the same reduced levels as that of the mock-irradiated heterozygous Tsc2 mice | 30508035 |
| 2020-04-11 12:32:00 | These data illustrate the critical importance of Tsc2 function in the Abcg2-expressing proximal tubule epithelium and mesenchyme during the development of cystic lesions and remodeling of kidney parenchyma. | 31461347 |
| 2020-04-11 10:36:00 | eIF2alphaP is a nodal point of mTORC1 signaling, which can determine the susceptibility of TSC2-deficient cells to oxidative insults and their efficacy in tumor formation in mice maintained on antioxidant diet. | 29449538 |
| 2020-04-04 11:06:00 | Nociceptor Deletion of Tsc2 Enhances Axon Regeneration by Inducing a Conditioning Injury Response in Dorsal Root Ganglia.These data show that neuronal mTORC1 activation induces an incomplete pro-regenerative environment in the DRG that improves initial but not later axon growth after nerve injury. | 31182472 |
| Type | IDs |
|---|---|
| Synonymous | Nafld, Tcs2 |
| Gene |
UniProtKB-ID:
A0A2I3BPP1_MOUSE,
Q3UG88_MOUSE,
Q7TT21_MOUSE,
Q3UGI8_MOUSE,
Q3UHB2_MOUSE,
Q3TQ10_MOUSE,
A0A2I3BRT5_MOUSE
UniprotKB:
A0A2I3BPP1,
Q3UG88,
Q7TT21,
Q3UGI8,
Q3UHB2,
Q3TQ10,
A0A2I3BRT5
UniParc:
UPI00005B2006,
UPI00005AC70F,
UPI00005AC746,
UPI000019B05D,
UPI0003C3CD6C,
UPI000024F32F,
UPI0000434D93
EMBL:
AK147908,
BC060701,
BC052449,
AK147487,
AC132367,
AK163991,
AK148062
Ensembl:
ENSMUSG00000002496
KO:
mmu:22084
|
| Nucleutide sequences |
EMBL-CDS:
BAE28321.1,
AAH52449.1,
AAH60701.1,
BAE28220.1,
BAE27945.1,
BAE37575.1
Ensembl_TRS:
ENSMUST00000226284,
ENSMUST00000097373,
ENSMUST00000226398,
ENSMUST00000227745,
ENSMUST00000227804,
ENSMUST00000228412
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000153869,
ENSMUSP00000153792,
ENSMUSP00000094986,
ENSMUSP00000154338,
ENSMUSP00000153864,
ENSMUSP00000154706
RefSeq:
NP_001273643.1,
XP_036016374.1,
XP_036016370.1,
XP_017172875.1,
NP_001273645.1,
XP_030105508.1,
NP_001273647.1,
XP_006524103.1,
XP_036016373.1,
XP_030105511.1,
XP_017172876.1,
XP_036016368.1,
NP_001273642.1,
NP_035777.2,
XP_017172881.1,
XP_036016376.1,
XP_017172882.1,
NP_001034452.1,
XP_017172877.1,
XP_030105506.1,
XP_017172879.1,
NP_001273649.1,
XP_017172874.1,
XP_036016371.1,
XP_017172873.1,
XP_017172878.1,
XP_030105507.1,
XP_036016375.1,
XP_036016372.1,
XP_006524107.1,
XP_036016369.1,
XP_030105510.1,
XP_017172880.1
|
| Others |
UniRef100:
UniRef100_Q3UG88,
UniRef100_Q3UHB2,
UniRef100_Q3TQ10,
UniRef100_Q7TT21,
UniRef100_A0A2I3BRT5,
UniRef100_A0A2I3BPP1,
UniRef100_Q3UGI8
UniRef90:
UniRef90_P49816
UniRef50:
UniRef50_P49815
UniGene:
Mm.30435
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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||||
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