| Type | Description |
|---|---|
| Definition | OTU deubiquitinase 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-24 14:04:00 | OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3. | 32075857 |
| 2019-10-05 11:10:00 | The data demonstrate that OTUD1 is involved in maintaining immune homeostasis and loss-of-function mutations of OTUD1 enhance the immune response and are associated with autoimmunity. | 30100102 |
| 2018-12-22 10:04:00 | Report that YAP is subject to non-proteolytic, K63-linked polyubiquitination by the SCF(SKP2) E3 ligase complex (SKP2), which is reversed by the deubiquitinase OTUD1. The non-proteolytic ubiquitination of YAP enhances its interaction with its nuclear binding partner TEAD, thereby inducing YAP's nuclear localization, transcriptional activity, and growth-promoting function. | 29891922 |
| 2018-12-01 12:03:00 | we report the establishment of OTUD1-specific monoclonal antibodies (mAbs), using the rat medial iliac lymph node method. The generated antibodies recognize the N-terminal portion (aa. 1-290) of human and mouse OTUD1 proteins | 30130141 |
| 2018-10-06 11:28:00 | OTU deubiquitinase 1 (OTUD1) directly deubiquitinates Smad7 Protein (SMAD7) and prevents its degradation. | 29235476 |
| Type | IDs |
|---|---|
| Synonymous | DUBA7, OTDC1 |
| Gene |
UniProtKB-ID:
OTUD1_HUMAN
UniprotKB:
Q5VV17
UniParc:
UPI0000458A32
EMBL:
AL512603
Ensembl:
ENSG00000165312
KO:
hsa:220213
|
| Nucleutide sequences |
Ensembl_TRS:
ENST00000376495
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000365678
RefSeq:
NP_001138845.1
|
| Others |
UniRef100:
UniRef100_Q5VV17
UniRef90:
UniRef90_Q5VV17
UniRef50:
UniRef50_Q5VV17
UniGene:
Hs.499042
CCDS:
CCDS44366.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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