| Type | Description |
|---|---|
| Definition | two pore segment channel 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-25 10:40:00 | cryo-EM structure of human TPC2 provides insights into the mechanism of PI(3,5)P2-regulated gating of TPC2, which is distinct from that of TPC1 | 30860481 |
| 2019-10-05 12:12:00 | support a role of TPC2 in autophagy progression and extracellular vesicle trafficking in cancer cells | 29990474 |
| 2018-09-29 10:10:00 | PI(3,5)P2-binding site in hTPC2 identified at positively charged amino acids (K203, K204, and K207) in the linker between transmembrane helices S4 and S5 and by S322 in the cytosolic extension of S6 and protein-lipid interface upon mutations of residues within the lipid-binding pocket had neither an effect on the binding behavior nor on the channel's lipid sensitivity. | 29705952 |
| 2018-06-30 10:53:00 | TPC2 polymorphisms are associated with a hair pigmentation. | 28923947 |
| 2018-06-30 10:17:00 | Data (including data from studies using tissue from knockout mice) suggest that beta-adrenergic stimulation of pancreas leads to glucagon secretion by hierarchy of calcium signaling in glucagon-secreting cell; such signaling is initiated by cAMP-induced TPC2-dependent calcium release from acidic stores and is further amplified by calcium release from endoplasmic reticulum. | 29563152 |
| Type | IDs |
|---|---|
| Synonymous | SHEP10, TPC2 |
| Gene |
UniProtKB-ID:
TPC2_HUMAN,
Q59G56_HUMAN
UniprotKB:
Q8NHX9,
Q59G56
UniParc:
UPI00004F6C1B,
UPI000013E149
EMBL:
AY029200,
AB209253,
AL137479,
BC063008,
AP003071
Ensembl:
ENSG00000162341
KO:
hsa:219931
|
| Nucleutide sequences |
EMBL-CDS:
AAK31802.1,
CAB70760.1,
AAH63008.1,
BAD92490.1
Ensembl_TRS:
ENST00000294309
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000294309
RefSeq:
NP_620714.2
|
| Others |
UniRef100:
UniRef100_Q8NHX9,
UniRef100_Q59G56
UniRef90:
UniRef90_Q59G56,
UniRef90_Q8NHX9
UniRef50:
UniRef50_Q59G56,
UniRef50_Q8NHX9
UniGene:
Hs.131851
CCDS:
CCDS8189.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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