| Type | Description |
|---|---|
| Definition | topoisomerase (DNA) II beta |
| Date | Results | Publications |
|---|---|---|
| 2020-01-11 10:03:00 | Loss of TOP2B negatively affects the B-cell development. | 31409799 |
| 2018-12-22 12:30:00 | Top2beta controls spinal motor neurons (MN) migration and connectivity; is not required for MN generation or survival; has a selective role in columnar specification. In absence of Top2beta, phrenic MN identity is eroded, while other motor columns are partially preserved but fail to cluster to their proper position. In Top2beta-/- mice, peripheral connectivity is impaired as MNs exhibit a profound deficit in terminal b... | 29379870 |
| 2018-05-12 11:48:00 | our data establish a combinatorial cell-autonomous and non-cell-autonomous role for Top2b in the late stage of photoreceptor differentiation and maturation | 28370415 |
| 2017-06-24 12:19:00 | We demonstrated that Nup98-TopIIbeta and Nup98-SETBP1 negatively regulate the XPO1-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98-fusion proteins induce tumorigenesis. | 28392395 |
| 2014-04-26 11:40:00 | TOP2beta as a factor involved in regulating granulosa cell genomic integrity and follicle atresia. | 24002654 |
| Type | IDs |
|---|---|
| Synonymous | D230016L12Rik, Top-2 |
| Gene |
UniProtKB-ID:
TOP2B_MOUSE
UniprotKB:
Q64511
UniParc:
UPI00001B06E5
EMBL:
BC054541,
BC041106,
D38046
Ensembl:
ENSMUSG00000017485
KO:
mmu:21974
|
| Nucleutide sequences |
EMBL-CDS:
AAH41106.1,
BAA07236.1,
AAH54541.1
Ensembl_TRS:
ENSMUST00000017629
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000017629
RefSeq:
NP_033435.2
|
| Others |
UniRef100:
UniRef100_Q64511
UniRef90:
UniRef90_Q64511
UniRef50:
UniRef50_Q64511
UniGene:
Mm.130362
CCDS:
CCDS26833.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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