| Type | Description |
|---|---|
| Definition | topoisomerase (DNA) II alpha |
| Date | Results | Publications |
|---|---|---|
| 2020-06-06 10:29:00 | TOP2-mediated double-strand breaks is a major driving force of thymic malignancies linked to ATM deficiency. | 32060399 |
| 2018-09-15 10:52:00 | RNF168 interacts with TOP2alpha to mediate its polyubiquitylation and RNF168 deficiency confers resistance to ICRF-193, a TOP2 catalytic inhibitor, and cytotoxic anti-cancer drug etoposide in cultured mouse cells. | 27558965 |
| 2017-12-02 10:52:00 | Topo IIalpha plays an important role in adipogenesis. | 27404349 |
| 2017-08-19 10:52:00 | Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II-targeting agents. | 27750031 |
| 2017-06-24 10:54:00 | TOP2 and BAF cooperate to recruit pluripotency factors, which explains some of the instructive roles of BAF complexes. | 28250416 |
| Type | IDs |
|---|---|
| Synonymous | Top-2 |
| Gene |
UniProtKB-ID:
TOP2A_MOUSE
UniprotKB:
Q01320
UniParc:
UPI00003540A8
EMBL:
AL591067,
U01915,
D12513
Ensembl:
ENSMUSG00000020914
KO:
mmu:21973
|
| Nucleutide sequences |
EMBL-CDS:
AAC52135.1,
BAA02076.1
Ensembl_TRS:
ENSMUST00000068031
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000068896
RefSeq:
XP_006533218.1,
NP_035753.2,
XP_006533217.1,
XP_006533216.1
|
| Others |
UniRef100:
UniRef100_Q01320
UniRef90:
UniRef90_Q01320
UniRef50:
UniRef50_Q01320
UniGene:
Mm.4237
CCDS:
CCDS25370.1
|
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|---|---|---|---|---|---|---|---|---|
| Refseq |
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