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21955 Tnnt1

21955

Tnnt1

troponin T1, skeletal, slow

protein-coding

Mus musculus

基因描述

Type Description
Definition troponin T1, skeletal, slow

研究结论

Date Results Publications
2020-08-22 15:30:00 The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy. 31148174
2019-03-16 10:16:00 Similar functional and histological phenotypes were observed in other human cohorts and two transgenic murine models (Tnnt1-/- and Tnnt1 c.505G>T). These findings have implications for emerging molecular therapies, including the suitably of TNNT1 gene replacement for newborns with 'Amish' nemaline myopathy or other TNNT1-associated myopathies. 29931346
2015-04-04 10:51:00 Mouse tumor endothelial cells express troponin T. 24810801
2015-02-21 13:12:00 demonstrated that ssTnT deficiency resulted in significantly decreased levels of other slow fibre-specific myofilament proteins whereas fast fibre-specific myofilament proteins were increased correspondingly 24445317
2010-01-21 00:00:00 the induction of Tnnt1 gene expression in adult mouse brains by ketamine may illustrate the genes involved in the metabolic syndromes observed in neuropsychiatric disorders 17850769

名称对应

Type IDs
Synonymous AW146156, Tnt, sTnT, ssTnT
Gene
UniProtKB-ID: TNNT1_MOUSE, Q3TVB8_MOUSE
UniprotKB: O88346, Q3TVB8
UniParc: UPI0000029652, UPI00000E8AB7, UPI00000E75CC
EMBL: BC141142, BC145451, U92882, U92884, AF020946, U92883, BC145450, AJ131711, AK160226, BC138871
Ensembl: ENSMUSG00000064179
KO: mmu:21955
Nucleutide sequences
EMBL-CDS: AAC32541.1, CAB38082.1, AAC32540.1, AAI45452.1, AAI45451.1, AAC32546.1, AAD00730.1, AAI41143.1, AAI38872.1, BAE35701.1
Ensembl_TRS: ENSMUST00000071798, ENSMUST00000163710, ENSMUST00000108587
Protein sequencees
Ensembl_PRO: ENSMUSP00000104228, ENSMUSP00000071704, ENSMUSP00000129626
RefSeq: XP_017177601.1, NP_001264833.1, XP_017177602.1, NP_001347083.1, XP_011248779.1, XP_017177603.1, NP_001264832.1, XP_017177600.1, XP_011248780.1, NP_035748.1
Others
UniRef100: UniRef100_O88346, UniRef100_Q3TVB8
UniRef90: UniRef90_J3QPC8, UniRef90_Q7TNB2
UniRef50: UniRef50_Q7TNB2
UniGene: Mm.358643
CCDS: CCDS71880.1, CCDS71879.1, CCDS51973.1

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