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21940 Cd27

21940

Cd27

CD27 antigen

protein-coding

Mus musculus

基因描述

Type Description
Definition CD27 antigen

研究结论

Date Results Publications
2020-05-30 11:16:00 results demonstrate a previously unappreciated role of CD27 stimulation as a positive regulator of IL-7Ralpha during CD8 T-cell responses, provide insights into the mechanistic basis by which CD27 stimulation influences CD8(+) T-cell memory differentiation. 31199542
2020-04-18 12:48:00 the results suggest that CD27 does not promote effector T cell survival by increasing expression of antiapoptotic BCL2 family members but instead acts by preferentially suppressing the cell-extrinsic apoptosis pathway, highlighting a previously unidentified role for CD27 in augmenting autoreactive effector T cell responses. 31209102
2020-01-25 14:47:00 CD27 and GITR co-stimulate antigen-dependent T cell activation. PD-1 efficiently inhibits T cell activation even with CD27 co-stimulation. 30771904
2019-09-14 12:31:00 The CD27 plays both redundant and distinct roles in regulating Regulatory T cells (Treg) plasticity in tissues. 30578350
2018-02-17 10:33:00 CD27 expression is upregulated in a subset of hematopoietic cluster cells, and CD27 marks hematopoietic stem cells (HSC), type II pre-HSCs, and progenitors with lymphoid potential within the cluster cells. 28588017

名称对应

Type IDs
Synonymous S152, Tnfrsf7, Tp55
Gene
UniProtKB-ID: CD27_MOUSE, B7ZW87_MOUSE, Q3U4X0_MOUSE, D3Z7W5_MOUSE
UniprotKB: P41272, B7ZW87, Q3U4X0, D3Z7W5
UniParc: UPI0000512617, UPI0000DACAD7, UPI0000023489
EMBL: AK153895, L24495, BC171931, BC139126, AC140324, BC139125, AK154005
Ensembl: ENSMUSG00000030336
KO: mmu:21940
Nucleutide sequences
EMBL-CDS: AAI71931.1, BAE32241.1, BAE32310.1, AAI39126.1, AAI39127.1
Ensembl_TRS: ENSMUST00000032486, ENSMUST00000112282, ENSMUST00000112281
Protein sequencees
Ensembl_PRO: ENSMUSP00000032486, ENSMUSP00000107901, ENSMUSP00000107900
RefSeq: NP_001028298.1, XP_006505961.1, NP_001273682.1, XP_006505964.1, NP_001036029.1, XP_006505963.1, XP_011239590.1
Others
UniRef100: UniRef100_P41272, UniRef100_D3Z7W5, UniRef100_B7ZW87
UniRef90: UniRef90_B7ZW87, UniRef90_D3Z7W5, UniRef90_P41272
UniRef50: UniRef50_D3Z7W5, UniRef50_B7ZW87, UniRef50_P41272
UniGene: Mm.367714
CCDS: CCDS39639.1

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